Pregnancy loss, recurrent, susceptibility

This trial tests whether a daily injection of granulocyte colony-stimulating factor (G-CSF), a protein that helps regulate the immune system, can improve pregnancy success in women with unexplained recurrent miscarriage after IVF. Only women whose embryos have been genetically co…

This study tests whether giving tranexamic acid (TXA) before a second-trimester dilation and evacuation (D&E) procedure can reduce heavy bleeding. Heavy bleeding is a rare but serious risk of D&E. The trial will include 276 pregnant people aged 18 and older who are between 18 and…

This study tests whether adding hydroxychloroquine (an anti-inflammatory drug) to levothyroxine (a thyroid hormone) can increase live birth rates in women with thyroid antibodies and unexplained recurrent pregnancy loss. About 800 women will take either the combination or levothy…

This study will test whether a 21-day spa program can improve hormone levels and well-being in 55 women aged 20-40 with infertility. Participants will receive comprehensive spa care including treatments and rehabilitation. The goal is to see if this approach can help reduce stres…

This study tests whether a paracervical block (an injection near the cervix) containing ketorolac and lidocaine can reduce pain during placement of osmotic dilators, which are used to prepare the cervix for a second-trimester abortion. About 76 participants will be randomly assig…

This study tests whether a brain-training technique called neurofeedback can help reduce anxiety in women who have had repeated pregnancy losses. Participants use a headband that monitors brain activity and plays a calming sound when the brain is in a relaxed state. The trial com…

This study tests if receiving weekly supportive messages during pregnancy can improve live birth rates and quality of life for people who have had multiple pregnancy losses. About 60 pregnant participants will interact with the messages and complete surveys. The goal is to see if…

This phase 2 trial tests whether a single dose of cabergoline can prevent breast engorgement, milk leakage, and tenderness after abortion or pregnancy loss at 12-18 weeks. About 348 participants will receive either cabergoline or a placebo right after the procedure and report sym…

This study looks at whether a single session of a brain stimulation technique called rTMS can change heart activity in women who have had multiple pregnancy losses and also have anxiety. Forty-six women will receive either real or fake stimulation while their heart rate is monito…

This study is looking at whether women with lower ovarian reserve (fewer eggs) have had more early miscarriages in the past. Researchers will measure ovarian reserve with a blood test (AMH) and an ultrasound (antral follicle count) in over 2,000 women seeking fertility care. This…

This study aims to discover the genetic reasons behind recurrent pregnancy loss (RPL) by analyzing DNA from parents and pregnancy tissue. Researchers at Yale University will enroll 500 women who have had multiple pregnancy losses. The goal is to identify genetic markers that pred…

This study follows 700 women who have had three or more early miscarriages or repeated implantation failures. Researchers will collect medical history, run tests, and track outcomes to find immune and genetic factors that may cause these losses. The goal is to better understand w…

This study looks at whether low levels of a protein called mannose-binding lectin (MBL) in the blood are linked to repeated pregnancy loss or failed IVF attempts. Researchers will measure MBL levels in 500 women with these conditions and compare them to the general population. Th…

This study looks at the bacteria living in the vagina and womb of women who have had two or more miscarriages. Researchers want to see if these bacterial communities differ from those in fertile women. The goal is to understand if the microbiome plays a role in recurrent pregnanc…

This study is following 20,000 women in China who had an induced abortion early in pregnancy (before 12 weeks). Researchers want to see if having an abortion in the past leads to more complications or problems in later pregnancies. The women will be tracked over time to compare t…