Posterior urethral valve
MONDO:0019640Posterior urethral valve (PUV) is the most common anomaly of fetal lower urinary tract obstruction (LUTO) and is characterized by an abnormal congenital obstructing membrane that is located within the posterior urethra associated with significant obstruction of the male bladder restricting normal bladder emptying.
Also known as: PUV, Posterior Urethral Valves, congenital posterior urethral valves, Posterior urethral valves
5 clinical trials for this condition and its sub-types.
Follow this condition — get notified about new trialsBroader categories
-
Could a common bladder drug help boys with rare birth defect?
Disease control Recruiting nowThis study tests whether giving oxybutynin syrup early (starting at 3-6 months old) can improve bladder function in boys born with posterior urethral valves, a condition that blocks urine flow. Fifty boys who had valve surgery will be randomly assigned to receive either oxybutyni…
Phase: PHASE2 • Sponsor: University Hospital, Bordeaux • Aim: Disease control
Last updated Jun 27, 2026 13:06 UTC
-
Double transplant: kidney and bladder together for the first time
Disease control Recruiting nowThis early-phase trial at Mayo Clinic is testing whether it is possible to transplant a bladder along with a kidney in people who have kidney failure due to bladder problems. Up to 30 participants will receive both organs from a deceased donor. The goal is to see if the bladder w…
Phase: EARLY_PHASE1 • Sponsor: Mayo Clinic • Aim: Disease control
Last updated Jun 27, 2026 12:23 UTC
-
What does life feel like for children with a rare birth defect? a new study asks
Knowledge-focused Recruiting nowThis study aims to understand the quality of life of school-aged children who were treated for posterior urethral valves (PUV) in their first year of life. PUV is a rare birth defect that can affect kidney and bladder function. Researchers will use a standard questionnaire called…
Sponsor: Hospices Civils de Lyon • Aim: Knowledge-focused
Last updated Aug 07, 2026 00:00 UTC