Polymyalgia rheumatica
MONDO:0019735A syndrome characterized by pain, stiffness, and tenderness of the proximal muscle groups including the shoulder, pelvic girdle and the neck. There is no muscle atrophy and muscle biopsies do not reveal pathologic changes. Additional signs and symptoms include low grade fever, fatigue and depression.
Also known as: polymyalgia rheumatica, rhizomelic pseudopolyarthritis
29 clinical trials for this condition and its sub-types.
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New hope for PMR patients: drug may replace long-term steroids
Disease control CompletedThis study tested two doses of secukinumab (a shot) combined with a steroid taper in 381 adults aged 50+ with polymyalgia rheumatica (PMR) who had recently relapsed. The goal was to see if secukinumab helps patients achieve and maintain remission without needing steroids long-ter…
Phase: PHASE3 • Sponsor: Novartis Pharmaceuticals • Aim: Disease control
Last updated Jun 27, 2026 14:01 UTC
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New drug could help patients with painful muscle disease ditch steroids
Disease control CompletedThis phase 3 trial tested whether abatacept, a drug that calms the immune system, can control polymyalgia rheumatica (a painful inflammatory condition) without the need for long-term steroids. Thirty-four adults with early disease received either abatacept or a placebo for 12 wee…
Phase: PHASE3 • Sponsor: University Hospital, Brest • Aim: Disease control
Last updated Jun 27, 2026 13:05 UTC
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New IV treatment explored for painful inflammatory conditions
Disease control CompletedThis study looked at how an intravenous (IV) form of secukinumab is processed by the body and whether it is safe for adults with giant cell arteritis (GCA) or polymyalgia rheumatica (PMR). These conditions cause inflammation in blood vessels or muscles, leading to pain and stiffn…
Phase: PHASE1 • Sponsor: Novartis Pharmaceuticals • Aim: Disease control
Last updated Jun 27, 2026 12:01 UTC
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New drug aims to tame blood vessel inflammation without steroids
Disease control CompletedThis study tested the drug secukinumab (Cosentyx) in 151 adults with newly diagnosed giant cell arteritis, a condition causing inflamed blood vessels. Participants were in remission and received either secukinumab or a placebo, along with a steroid taper. The goal was to see if s…
Phase: PHASE3 • Sponsor: Novartis Pharmaceuticals • Aim: Disease control
Last updated Jun 27, 2026 09:08 UTC
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New hope for PMR patients: drug may reduce need for steroids
Disease control CompletedThis study tested whether rituximab, a drug that calms the immune system, can help people with polymyalgia rheumatica (PMR) stop taking steroids sooner. PMR causes pain and stiffness, and steroids are the main treatment but have side effects. The trial included 114 newly diagnose…
Phase: PHASE3 • Sponsor: Sint Maartenskliniek • Aim: Disease control
Last updated Jun 27, 2026 09:01 UTC
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New study links common arthritis treatments to diabetes risk
Knowledge-focused CompletedThis observational study followed 198 adults aged 50–85 with giant cell arteritis or polymyalgia rheumatica to understand how common treatments (glucocorticoids and interleukin-6 inhibitors) affect diabetes risk. Researchers tracked blood sugar levels and other markers over time.…
Sponsor: Salome Kristensen • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:26 UTC