Pneumocystosis
MONDO:0019121Human pneumocystosis is caused by an infectious agent, which (after recent nomenclature and taxonomy revisions) is now classed as the fungus Pneumocystis jiroveci. The prevalence is unknown. Pneumocystis jiroveci is an opportunistic infectious agent, developing in immunosuppressed patients. It is an air-borne infection, localized to the lungs. However, extrapulmonary involvement is seen in AIDS patients. The disease manifests progressively with coughing, respiratory problems (dyspnea) and fever, followed by acute respiratory insufficiency and death within a few weeks in untreated cases. The most reliable diagnostic method is bronchoalveolar lavage. The treatment of choice is cotrimoxazole.
Also known as: PCP, PJP, Pneumocystis, Pneumocystis Pneumonia, Pneumocystis carinii pneumonia, Pneumocystis jirovecii pneumonia, Pneumocystis pneumonia, pneumocystosis
67 clinical trials for this condition and its sub-types.
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Could a shorter steroid course be just as good for HIV-Related pneumonia?
Disease control ENROLLING_BY_INVITATIONThis study compares a shortened steroid regimen (8 days for moderate, 14 days for severe pneumonia) against the standard 21-day course in 196 HIV patients with Pneumocystis pneumonia. The goal is to see if the shorter treatment is non-inferior in preventing death and complication…
Phase: NA • Sponsor: Centro de Investigación en. Enfermedades Infecciosas, Mexico • Aim: Disease control
Last updated Jun 27, 2026 12:01 UTC
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New rapid test could slash unnecessary antibiotic use in emergency rooms
Diagnosis OngoingThis study tests a fast point-of-care PCR test (Spotfire) that quickly identifies whether a respiratory infection is caused by a virus. The goal is to give ER doctors results faster so they can avoid prescribing antibiotics when they won't help. The trial enrolls 200 adults with …
Phase: NA • Sponsor: Christopher Payette • Aim: Diagnosis
Last updated Jun 27, 2026 07:58 UTC
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Scientists sniff out virus spread with home air monitors
Knowledge-focused TerminatedThis study looks at whether air samplers placed in homes can detect viruses that cause colds and flu, and how that compares to standard nasal swabs. About 422 students and their families will participate. The goal is to better understand how respiratory viruses spread through hou…
Phase: NA • Sponsor: University of Wisconsin, Madison • Aim: Knowledge-focused
Last updated Jun 27, 2026 13:06 UTC
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Could a simple spit test replace the dreaded deep nose swab?
Knowledge-focused OngoingThis study compares new, less invasive ways to collect samples for respiratory virus testing—like a nasal wash or saliva—against the standard deep nose swab. Researchers want to see if these gentler methods work just as well and cause less pain. About 1,000 adults in the emergenc…
Phase: NA • Sponsor: University of Nebraska • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:08 UTC
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15-Minute nasal swab could curb antibiotic overuse for colds
Knowledge-focused ENROLLING_BY_INVITATIONThis study places a rapid testing device in primary care clinics to help doctors quickly identify whether a cold-like illness is caused by a virus or bacteria. About 8,000 adults with symptoms like cough or runny nose will get a nasal swab, with results in 15 minutes. The goal is…
Phase: NA • Sponsor: University of Pennsylvania • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:06 UTC