Periodic fever syndrome
MONDO:0015137Fevers of unknown etiology recurring over months or years.
60 clinical trials for this condition and its sub-types.
Follow this condition — get notified about new trialsSub-types
Broader categories
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Pausing arthritis drug may boost pneumonia Shot's power
Disease control Not yet recruitingThis study tests whether temporarily stopping methotrexate for 2 weeks after receiving a pneumonia vaccine (PCV20) helps the vaccine work better in adults with autoimmune rheumatic diseases like rheumatoid arthritis or lupus. About 192 participants with stable, low disease activi…
Phase: PHASE4 • Sponsor: University of Sao Paulo General Hospital • Aim: Disease control
Last updated Jun 27, 2026 12:00 UTC
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Old drug, new hope: thalidomide tested for Kids' fever disorder
Disease control Not yet recruitingThis study tests whether thalidomide can reduce or stop fever episodes in children with PFAPA syndrome, a condition causing repeated fevers and sore throats. About 106 children aged 3 to 18 will take either thalidomide or colchicine daily for 6 months. Researchers will track how …
Phase: NA • Sponsor: Wenjie Zheng • Aim: Disease control
Last updated Jun 27, 2026 11:03 UTC
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New blood markers may speed up diagnosis of childhood arthritis and fevers
Diagnosis Not yet recruitingThis study looks at two substances in the blood, IL-18 and IL-18BP, to see if they can help doctors tell apart different causes of fever in children. Researchers will measure these levels in 9 children with conditions like juvenile arthritis, autoinflammatory diseases, or serious…
Sponsor: IRCCS Azienda Ospedaliero-Universitaria di Bologna • Aim: Diagnosis
Last updated Jun 27, 2026 11:01 UTC
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Can a quick quiz replace gym tests for kids with chronic illness?
Knowledge-focused Not yet recruitingThis study checks whether two short questionnaires can accurately measure physical fitness in children aged 10–18 with juvenile idiopathic arthritis or familial Mediterranean fever. Researchers will compare the questionnaire results with standard fitness tests. If the questionnai…
Sponsor: Istanbul University - Cerrahpasa • Aim: Knowledge-focused
Last updated Jun 27, 2026 13:00 UTC
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Skin glow may predict inflammation in FMF patients
Knowledge-focused Not yet recruitingThis study looks at whether a painless skin scan can measure long-term inflammation in people with Familial Mediterranean Fever (FMF). Researchers will compare these skin measurements with a blood-based inflammation score called the CALLY index. The goal is to better understand o…
Sponsor: Bursa City Hospital • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:08 UTC
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Can a quick skin scan reveal hidden inflammation in arthritis?
Knowledge-focused Not yet recruitingThis study will measure harmful molecules called AGEs in 300 people with various rheumatic diseases (like rheumatoid arthritis and ankylosing spondylitis) and compare them to healthy volunteers. AGEs build up over time and can cause inflammation. Researchers will use a non-invasi…
Sponsor: Bursa City Hospital • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:10 UTC
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Hidden mouth signs of FMF in kids revealed
Knowledge-focused Not yet recruitingThis study will check 359 Egyptian children aged 6 to 15 with Familial Mediterranean Fever for mouth problems like ulcers, enamel defects, and high-arched palate. Researchers will do a dental exam and review medical records. The goal is to find out how common these oral issues ar…
Sponsor: Cairo University • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:59 UTC
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New blood tests aim to unlock mysteries of rare inflammatory diseases
Knowledge-focused Not yet recruitingThis study aims to better understand rare autoinflammatory diseases by developing blood tests that measure inflammation markers. Researchers will analyze blood samples from 60 adults and children with these conditions. The goal is to identify specific inflammation pathways, which…
Sponsor: Hospices Civils de Lyon • Aim: Knowledge-focused
Last updated Jun 26, 2026 17:44 UTC