Perinatal necrotizing enterocolitis
MONDO:0004639A fulminating disease of neonates in which there is extensive mucosal ulceration, pseudomembrane formation, submucosal hemorrhage, and necrosis usually of the right colon, cecum, terminal ileum, and appendix, possibly due to perinatal intestinal ischemia and bacterial invasion. Progression can lead to necrosis, perforation and/or scarring of the intestinal tract.
Also known as: enterocolitis necrotizing, necrotizing enterocolitis, necrotizing enterocolitis in foetus or newborn, enterocolitis, necrotizing
13 clinical trials for this condition and its sub-types.
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Simple drug may cut infection risk after major gut surgery
Disease control CompletedThis study tested whether tranexamic acid, a drug that helps blood clot, can lower the chance of infection after gastrointestinal surgery. Over 3,300 adults at higher risk for complications took part. The goal was to see if the drug reduces surgical site infections compared to a …
Phase: PHASE4 • Sponsor: Bayside Health • Aim: Disease control
Last updated Jun 27, 2026 08:07 UTC
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Probiotics show promise for preterm infants: could reduce deadly gut infections
Disease control CompletedThis study tested whether giving probiotics (single or multiple strains) to 249 premature babies for 28 days after birth could prevent necrotizing enterocolitis, sepsis, and improve growth. The babies were born before 36 weeks and weighed under 2500 grams. Researchers compared a …
Phase: PHASE4 • Sponsor: Madiha, MPhil • Aim: Disease control
Last updated Jun 27, 2026 08:05 UTC
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Probiotic drops may shield preemies from fatal gut infection
Disease control CompletedThis study tested whether giving a probiotic (Lactobacillus reuteri) to premature infants could reduce the risk of necrotizing enterocolitis (NEC), a severe gut infection, and death. One hundred babies born between 28 and 36 weeks and weighing 1000-2500 grams were enrolled. The p…
Phase: NA • Sponsor: University of Health Sciences Lahore • Aim: Disease control
Last updated Jun 26, 2026 16:23 UTC
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Can an online wellness program ease anxiety in chronic disease?
Symptom relief CompletedThis study tested a 12-week online mind-body program for adults with chronic conditions like heart failure, cancer, and liver disease. The program included mindful movement, meditation, breathwork, and coping skills. Researchers measured changes in anxiety, depression, fatigue, a…
Phase: NA • Sponsor: University of Alberta • Aim: Symptom relief
Last updated Jun 27, 2026 12:31 UTC
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NICU antibiotic study questions routine use for tiniest babies
Knowledge-focused CompletedThis study looked at whether giving antibiotics early to extremely low birthweight babies (born before 31 weeks) might cause more harm than good. Researchers compared babies who got standard antibiotics to those who got a placebo. The goal was to see if early antibiotics increase…
Phase: PHASE4 • Sponsor: Michael Morowitz • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:23 UTC
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Computer models aim to predict deadly infections in fragile newborns
Knowledge-focused CompletedThis pilot study tested whether computer models could predict sepsis and necrotizing enterocolitis (NEC) in very low birth weight infants (under 1500 grams). Researchers used existing NICU data to build and test these models. The goal was to see if this approach is feasible, not …
Sponsor: University of Virginia • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:05 UTC
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New care bundle aims to slash deadly gut disease in preterm babies
Knowledge-focused CompletedThis study looks at whether a set of guidelines called the EMNODN NEC Care Bundle helps very preterm babies (born before 32 weeks) get more of their own mother's milk and reduces a life-threatening gut condition called necrotising enterocolitis (NEC). Researchers will compare dat…
Sponsor: University Hospitals of Derby and Burton NHS Foundation Trust • Aim: Knowledge-focused
Last updated Jun 26, 2026 14:57 UTC