Papillon-Lefevre disease
MONDO:0009490Papillon-Lefevre syndrome (PLS) is a rare ectodermal dysplasia characterized by palmoplantar keratoderma associated with early-onset periodontitis.
Also known as: PLS, Papillon Lefèvre Syndrome, keratosis palmoplantar-periodontopathy syndrome, Keratoris palmoplantaris with periodontopathia, PALS, PAPILLON-Lefevre syndrome, Papillon-LEFèvre syndrome, Pls
24 clinical trials for this condition and its sub-types.
Follow this condition — get notified about new trialsBroader categories
-
Your extracted tooth could save your jawbone for implants
Disease control ENROLLING_BY_INVITATIONThis study tests whether a patient's own stored tooth can be used as a graft to preserve jawbone after tooth extraction. About 21 adults needing at least two teeth pulled will receive this treatment. The goal is to maintain bone width and height for better future dental implant p…
Sponsor: Istanbul Saglik Bilimleri University • Aim: Disease control
Last updated Jun 27, 2026 12:30 UTC
-
AI and volunteers team up to fight gum disease in seniors
Disease control OngoingThis study tests whether personalized oral hygiene advice, delivered through an AI-powered mobile health app by trained volunteers, can improve gum health in older adults. Eighty-eight participants aged 60 and over from daycare centers in Hong Kong will receive bi-weekly advice b…
Phase: NA • Sponsor: The University of Hong Kong • Aim: Disease control
Last updated Jun 27, 2026 12:25 UTC
-
New hope for ALS patients: experimental drug CNM-Au8 now available through expanded access
Disease control TEMPORARILY_NOT_AVAILABLEThis program provides early access to an experimental drug called CNM-Au8 for people with amyotrophic lateral sclerosis (ALS), a progressive nerve disease. Participants must be 18 or older and have a confirmed ALS diagnosis. The goal is to offer treatment to those who cannot join…
Sponsor: Clene Nanomedicine • Aim: Disease control
Last updated Jun 27, 2026 12:04 UTC
-
Desperate patient gets experimental stem cells for rare nerve disease
Disease control NO_LONGER_AVAILABLEThis study provides an experimental stem cell treatment (HB-adMSCs) to an 83-year-old man with Primary Lateral Sclerosis, a rare nerve disease that causes progressive muscle weakness. The patient's own banked stem cells are used, aiming to slow the disease. This is a single-patie…
Sponsor: Hope Biosciences Research Foundation • Aim: Disease control
Last updated Jun 27, 2026 07:52 UTC
-
3D-Printed short implants could offer new option for jawbone loss
Knowledge-focused ENROLLING_BY_INVITATIONThis study follows 100 people who already have short, 3D-printed dental implants in the back of the upper or lower jaw. Researchers measure bone loss and other dental health markers over three years to see how well these implants hold up. The goal is to learn whether these specia…
Sponsor: University of Guarulhos • Aim: Knowledge-focused
Last updated Jul 19, 2026 00:00 UTC