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Palmoplantar keratosis
MONDO:0006590A group of autosomal dominant, autosomal recessive, X-linked inherited or acquired disorders characterized by the thickening of the palms and soles due to hyperkeratosis.
Also known as: palmoplantar keratoderma, keratoderma, palmoplantar
21 clinical trials for this condition and its sub-types.
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Broader categories
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Could a psoriasis drug help thickened hands and feet?
Disease control OngoingThis study tests a daily cream called tapinarof, already used for psoriasis, in 6 adults with palmoplantar keratoderma — a condition that causes painful thickening of skin on the palms and soles. Researchers want to see if the cream can clear or improve the skin and check for sid…
Phase: PHASE2 • Sponsor: Indiana University • Aim: Disease control
Last updated Jun 27, 2026 14:02 UTC
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New hope for ALS patients: experimental drug CNM-Au8 now available through expanded access
Disease control TEMPORARILY_NOT_AVAILABLEThis program provides early access to an experimental drug called CNM-Au8 for people with amyotrophic lateral sclerosis (ALS), a progressive nerve disease. Participants must be 18 or older and have a confirmed ALS diagnosis. The goal is to offer treatment to those who cannot join…
Sponsor: Clene Nanomedicine • Aim: Disease control
Last updated Jun 27, 2026 12:04 UTC
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Desperate patient gets experimental stem cells for rare nerve disease
Disease control NO_LONGER_AVAILABLEThis study provides an experimental stem cell treatment (HB-adMSCs) to an 83-year-old man with Primary Lateral Sclerosis, a rare nerve disease that causes progressive muscle weakness. The patient's own banked stem cells are used, aiming to slow the disease. This is a single-patie…
Sponsor: Hope Biosciences Research Foundation • Aim: Disease control
Last updated Jun 27, 2026 07:52 UTC
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AI vs. skin doctors: who diagnoses better?
Knowledge-focused ENROLLING_BY_INVITATIONThis study looks at whether artificial intelligence (AI) can match a dermatologist's diagnosis when a general practitioner sends in photos and questions about a patient's skin condition. Researchers will compare the AI's diagnosis to the dermatologist's for about 1000 adults. The…
Sponsor: Centre Hospitalier Universitaire de Nice • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:11 UTC