Oral mucosa leukoplakia

This trial tests whether pembrolizumab (Keytruda), an immunotherapy drug that helps the immune system attack abnormal cells, can shrink or control leukoplakia—a precancerous condition of the mouth. The study includes people with leukoplakia or related lesions that cannot be remov…

This study tests if injecting the cancer drug nivolumab directly into high-risk precancerous mouth lesions can stop them from turning into cancer. About 45 adults with these lesions will receive either the drug or a placebo injection. The goal is to see if the treatment is safe a…

This study tests whether a combination of two diabetes drugs, pioglitazone and metformin, can shrink or improve precancerous patches in the mouth called oral leukoplakia. About 36 adults with high-risk lesions will take the pills twice daily for 12 weeks. The goal is to see if th…

This study tests if a cream called imiquimod can treat pre-cancerous spots in the mouth. Twenty adults with these spots will apply the cream and get two follow-up biopsies. The goal is to see if the spots shrink and if the abnormal cells become less severe.

This study tests whether metformin, a diabetes drug, can shrink or prevent precancerous mouth patches called oral leukoplakia. Researchers will give 34 adults a metformin gel applied to the lesion plus a metformin pill, or placebos. The goal is to see if the combination reduces l…

This study tests whether gels made with coenzyme Q10 or curcumin can shrink or stabilize precancerous white patches in the mouth called oral leukoplakia. About 34 adults with mild patches that don't need surgery will apply the gel daily. The goal is to see if these antioxidants c…

This study tests a new imaging device called the Active Biopsy Guidance System to help doctors decide when and where to take tissue samples (biopsies) from mouth lesions. About 90 adults with suspicious mouth spots or a history of oral cancer will participate. The goal is to see …

This study tests whether using mobile health (mHealth) tools helps find early signs of oral cancer better than the usual visual exam in rural areas of Varanasi, India. Over 5,000 adults with risk factors like smoking, tobacco use, or age over 40 will be screened. The goal is to c…

This study is for 1000 people with oral cancer or precancerous mouth lesions. Researchers will collect tissue samples and ask participants about their symptoms before, during, and after treatment. The goal is to find better ways to predict how the disease will behave and which tr…