Non-classic congenital lipoid adrenal hyperplasia due to STAR deficency

This study looked at the long-term safety of a drug called ARO-APOC3 in adults with dyslipidemia (abnormal fat levels in the blood). Participants who completed a previous 12-month study could continue receiving the drug every 3 or 6 months. The goal was to see if the drug remains…

This study tested a low dose (10 mg) of the statin drug rosuvastatin in 242 Korean adults with high cholesterol or heart disease risk. The goal was to see how much it lowered 'bad' LDL cholesterol after 8 weeks. Results help guide cholesterol treatment in this population.

This study looked at 99 IVF patients with endometriosis (a condition where uterine-like tissue grows elsewhere) and a positive BCL6 test. It compared a cheap oral pill (norethindrone acetate) to an expensive injection (Depo Lupron) given before embryo transfer. The goal was to se…

This study tested a ready-to-use calcium ionophore medium (GM508 CultActive) on eggs from 68 IVF patients who had low fertilization rates, poor embryo quality, or were over 40. The medium was applied shortly after sperm injection to try to improve fertilization and embryo develop…

This study tested whether giving a small daily dose of a hormone (human menopausal gonadotropin) after egg retrieval could improve the chance of a live birth in women undergoing IVF. 600 women aged 20-40 took part. The researchers compared live birth rates between those who got t…

This study looked at whether adding vaginal estradiol or oral guaifenesin to standard fertility treatment (clomiphene citrate) could improve pregnancy rates. 90 women with infertility were randomly assigned to one of three groups. The goal was to see if these add-ons helped with …

This study tested whether a drug called alirocumab, which lowers cholesterol, can reduce heart disease risk in people with HIV. The trial involved 118 adults aged 40 and older with well-controlled HIV and high heart disease risk. Participants received either alirocumab or a place…

This completed trial tested a new device called HyperSperm that prepares sperm for IVF or ICSI. Researchers compared it to standard sperm preparation in 41 couples. The goal was to see if the new method leads to more embryos reaching the blastocyst stage, which is key for success…

This study tested a microfluidic chip that gently separates healthy, motile sperm from semen without harsh chemicals. Researchers compared it to the standard spinning method in 393 couples undergoing IVF for unexplained infertility. The goal was to see if the chip leads to higher…

This early-stage study tested a new medicine called ARO-ANG3 in 93 people, including healthy volunteers and patients with high cholesterol or high triglycerides. The main goal was to check if the drug is safe and how the body processes it. This research helps determine if the dru…

This study tested a high dose of a fertility drug called follitropin delta, mixed with another hormone (hCG), in 118 women undergoing IVF. The goal was to see if this combination could improve the number of good-quality embryos. The study was completed and focused on women aged 1…

This study tested two different chemotherapy drugs (Treosulfan and Busulfan) given before a stem cell transplant in 106 children with serious non-cancer diseases like immune disorders, metabolic diseases, blood disorders, and bone marrow failure. The goal was to see which drug le…

This study tested two new technologies—optical genome mapping and long-read DNA sequencing—against standard chromosome tests in 350 people with infertility, intellectual disability, birth defects, or miscarriage. The goal was to see if these newer methods can find more chromosome…

This study tested a new method called global metabolomic profiling to diagnose inborn errors of metabolism, a group of rare genetic disorders. Researchers compared this approach to traditional testing in 240 participants. The goal was to see if the new method could more accuratel…

This study tested whether taking melatonin, a natural antioxidant, can improve egg quality and pregnancy rates in women undergoing IVF. Eighty infertile women received either melatonin or a placebo. Researchers measured melatonin levels in ovarian fluid and tracked egg maturation…

This study created a registry of medical records from women with inborn errors of metabolism—rare conditions that affect how the body turns food into energy. Researchers collected data from past or current pregnancies and followed babies for one year after birth. The goal was to …

This study aimed to find new gene changes that cause rare lipid disorders. Researchers used advanced genetic testing to look at many genes at once in 140 people and their relatives. The goal was to discover causes that older methods missed.

This completed study looked at how the social networks of caregivers affect their stress and health when caring for someone with an inherited disease. Researchers surveyed over 680 participants, including family members and formal caregivers, to understand caregiving burden and s…

This study tested a device called the Alife Hera System, which uses a computer algorithm to score embryos based on images and patient information. The goal was to see if using this score alongside standard methods helps doctors choose the embryo most likely to result in a pregnan…

This study reviewed 1251 intrauterine insemination (IUI) cycles at one hospital to see if the type of fertility drug used or the cause of infertility affected pregnancy rates. Participants were women aged 20-44 with normal ovulation and their partners with adequate sperm. The res…

This study looked at how fat-carrying particles called lipoproteins work in healthy people and those with high cholesterol or other lipid disorders. Researchers injected tiny, safe amounts of radioactive lipoproteins to track them in the body. The goal was to better understand ho…

This completed observational study at Uşak University examined 150 adults hospitalized in the endocrinology department. Researchers measured breathing, muscle strength, pain, fatigue, sleep quality, physical activity, balance, and nerve function. The goal was to better understand…

This study looked at 99 people with high heart risk to understand how a protein called CETP affects plaque buildup in arteries. Researchers measured CETP activity, artery thickness, and calcium scores. The goal was to learn more about heart disease, not to test a new treatment.

This study looked at 110 women aged 35-40 with low ovarian reserve undergoing IVF. Half received a mild stimulation (clomiphene plus low-dose hormones) and half received a stronger stimulation (higher-dose hormones). The goal was to see which approach led to more good-quality bla…

This study looked at whether using frozen embryos instead of fresh ones in IVF leads to more live births. 237 women took part, and researchers compared pregnancy rates and baby health. The goal was to see if freezing embryos helps the womb lining work better.

This study looked at over 5,800 couples who had a first baby through fertility treatment at an Italian clinic. Researchers wanted to see how many came back for more treatment to have a second or third child, and what factors—like age or frozen embryos—affected that decision. The …

This study looked at whether the level of thyroid-stimulating hormone (TSH) in the blood affects the success of a fertility treatment called ICSI. Researchers measured TSH in 180 women on day 2-3 of their menstrual cycle and then tracked egg retrieval, fertilization, and pregnanc…

This study compared two advanced embryo culture systems used in IVF with ICSI. One system has a built-in camera to watch embryos continuously, while the other uses periodic microscope checks. Researchers wanted to see if either system leads to more embryos implanting successfully…

This study tested an artificial intelligence tool called EMA to see if it can rank embryos better than traditional methods for IVF. Researchers looked at data from 333 people who had IVF between 2022 and 2023. The goal was to see if the AI's scores matched up with expert embryolo…

This study looked at over 1,200 women under 40 who had a frozen embryo transfer. Some used a natural cycle with no hormones, while others took estrogen and progesterone to mimic a natural cycle. The goal was to see which method leads to more pregnancies. Results could help clinic…

This study looked at 158 women having intrauterine insemination (IUI) to see if progesterone levels on the day of insemination are linked to pregnancy rates. IUI is a simpler, cheaper fertility treatment than IVF, but success rates are low. Researchers measured progesterone and o…

This study looked at how many girls and young women aged 11 to 20 with chronic diseases (like diabetes or immune conditions) got the HPV vaccine, compared to those without chronic illness. Researchers reviewed records of 223 participants from a hospital in France. The goal was to…

This study tested a robotic assistant to automate key steps in the IVF lab, such as preparing sperm and eggs, injecting sperm into eggs (ICSI), and freezing embryos. Researchers compared the robot's performance to standard manual methods using eggs and embryos from 42 couples und…

This study observed 201 women in Nordic countries and Switzerland who were using the fertility drug REKOVELLE® for the first time during IVF or ICSI. Researchers tracked how doctors prescribed the drug, including dose adjustments and use of a dosing app, to understand real-world …

This study looked at whether flushing the uterus with a low dose of the hormone hCG right after egg retrieval could improve pregnancy rates in women undergoing IVF. Researchers measured immune markers and blood flow in the uterus to see if the flush made the womb more receptive t…

This study looked at 87 women who had no eggs retrieved during their first IVF cycle. Researchers wanted to see if a second round of ovulation-inducing medication could lead to successful egg retrieval. The goal was to understand which factors might predict failure and how to imp…

This study looked at genes in cumulus cells (cells that surround eggs) from 137 women undergoing IVF. The goal was to find genetic markers that predict which embryos are most likely to lead to a pregnancy. Researchers compared two different hormone treatments to see if gene patte…