Narcolepsy without cataplexy

This trial tests whether a concentrated beverage taken daily for 28 days can improve sleep quality in adults aged 18 to 60 with mild sleep issues. Participants keep sleep diaries and complete questionnaires on sleep quality and fatigue. The study uses a single-arm design, meaning…

This study tests a drug called samelisant in 240 people with narcolepsy (with or without cataplexy). The goal is to see if it reduces excessive daytime sleepiness and sudden muscle weakness episodes over 12 weeks. Participants will take the drug or a placebo and report their slee…

This Phase 3 study tests whether expanded dosing regimens of Xywav can safely reduce excessive daytime sleepiness in adults with narcolepsy or idiopathic hypersomnia. About 108 participants will receive either Xywav or a placebo in a randomized withdrawal design. The main goal is…

This study tests whether a drug called gamma-hydroxybutyrate (GHB) can help intensive care patients get better deep sleep. Sleep problems are very common in the ICU and can lead to serious issues like confusion and longer recovery. The trial will give GHB or a placebo to 24 adult…

This study tests a slow-release melatonin (PedPRM) in 120 children aged 6 to 18 who have anorexia nervosa and trouble sleeping. Participants take either melatonin or a placebo for 13 weeks. The goal is to see if it safely improves total sleep time and related symptoms like anxiet…

This study evaluates whether several sleepiness questionnaires are reliable for children and adolescents aged 6 to 17. It includes three groups: children from the general population, those with sleep disorders or conditions like narcolepsy or ADHD, and healthy volunteers. The goa…