Mast cell activation syndrome
MONDO:0100004A clinically defined disease states with a largely unknown morphological background. Acute mast cell activation (MCA) is commonly seen in allergic reactions and often leads to the clinical signs and symptoms of anaphylaxis. Severe or even life‐threatening MCA may occur when the burden of mast cells is high and/or these cells are in an hyperactivated state. Mastocytosis may be associated with mast cell activation syndrome (MCAS).
Also known as: MACS, disorder of mast cell activation, mast cell activation disease
9 clinical trials for this condition and its sub-types.
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Broader categories
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New hope for Tick-Bite survivors: mast cell drugs aim to ease lingering symptoms
Symptom relief Not yet recruitingThis study tests whether medications that calm mast cells (ketotifen and cromolyn) can safely reduce persistent symptoms like fatigue, pain, and brain fog in people who had a tick-borne illness. Fifty adults aged 21-65 will receive either one of these drugs or a standard antihist…
Phase 2 • Sponsor: University of North Carolina, Chapel Hill • Aim: Symptom relief
Last updated Jun 27, 2026 12:07 UTC
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Long-Term study aims to unlock mystery of joint hypermobility and chronic illness
Knowledge-focused Not yet recruitingThis study will follow 100 health science students for at least 10 years to understand why some people with very flexible joints (hypermobility) develop chronic pain, fatigue, and other health issues while others do not. Researchers will measure balance, heart rate, and quality o…
Sponsor: Clarkson University • Aim: Knowledge-focused
Last updated Jun 27, 2026 14:01 UTC