Mast cell activation syndrome

MONDO:0100004

A clinically defined disease states with a largely unknown morphological background. Acute mast cell activation (MCA) is commonly seen in allergic reactions and often leads to the clinical signs and symptoms of anaphylaxis. Severe or even life‐threatening MCA may occur when the burden of mast cells is high and/or these cells are in an hyperactivated state. Mastocytosis may be associated with mast cell activation syndrome (MCAS).

Also known as: MACS, disorder of mast cell activation, mast cell activation disease

9 clinical trials for this condition and its sub-types.

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Sub-types

Idiopathic mast cell activation syndrome (1) Monoclonal mast cell activation syndrome (1) Secondary mast cell activation syndrome (0)

Broader categories

Disease (717) Hematologic disorder (172) Immune system disorder (150) Human disease (15) Leukocyte disorder (6) Disease by body system or component (0)

Trials to join now! 4 Not yet recruiting 2 Not yet finished but already full! 1 Completed 1 Terminated 1

Pain relief drug trial for mast cell syndrome stalls early

Symptom relief Stopped early

This Phase 2 trial tested whether FSD201 tablets could reduce chronic pain in adults with mast cell activation syndrome. The study planned to enroll many participants but was terminated early with only 2 people. No results are available to show if the drug works or is safe.

Phase 2 • Sponsor: Quantum Biopharma • Aim: Symptom relief

Last updated Jun 27, 2026 12:23 UTC

Mast cell activation syndrome

Sub-types

Broader categories

Pain relief drug trial for mast cell syndrome stalls early