Major affective disorder 4
MONDO:0012642Also known as: MAFD4, major affective disorder 4, MAJOR affective disorder 4, bipolar affective disorder
101 clinical trials for this condition and its sub-types.
Follow this condition — get notified about new trialsBroader categories
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New therapy aims to help teens battling addiction and anxiety
Disease control CompletedThis study tests a new behavioral therapy called OPT-A for teenagers who have both substance use problems and mood or anxiety disorders. 140 teens aged 10-17 will receive either OPT-A or standard treatment. Researchers will track substance use and mental health for 18 months to s…
Phase: NA • Sponsor: Medical University of South Carolina • Aim: Disease control
Last updated Jun 27, 2026 13:06 UTC
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New community program targets COPD and mental health together
Disease control CompletedThis completed trial in Xishui, China, tested a community-based program for 3,571 adults aged 35 and older who were at high risk for COPD and had mental health symptoms. The program included lung function tests, digital mental health support, smoking cessation help, and health ed…
Phase: NA • Sponsor: Peking Union Medical College • Aim: Disease control
Last updated Jun 27, 2026 13:03 UTC
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Can one doctor visit tackle both addiction and depression?
Disease control CompletedThis study tested whether a team-based care model can help people with both opioid use disorder and mental health issues like depression or anxiety. 254 adults in primary care received either full collaborative care for both conditions or just mental health support. The goal was …
Phase: NA • Sponsor: University of Washington • Aim: Disease control
Last updated Jun 27, 2026 07:53 UTC
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Mediterranean diet shows promise for metabolic health in psychiatric patients
Disease control CompletedThis completed study tested whether a Mediterranean diet could improve metabolic syndrome markers in 30 hospitalized adults with psychiatric conditions. Participants followed either a Mediterranean diet or a standard hospital diet for 8 weeks, then switched. Researchers measured …
Phase: NA • Sponsor: King Saud University • Aim: Disease control
Last updated Jun 26, 2026 15:01 UTC
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Nurse Check-Ins after suicide attempt show promise in preventing repeat crisis
Prevention CompletedThis study tested whether personalized, intensive nursing follow-up (by phone, home visits, or hospital consultations) after a suicide attempt could prevent another attempt or crisis in people with mood disorders. 380 participants were followed for one year. The goal was to see i…
Phase: NA • Sponsor: University Hospital, Montpellier • Aim: Prevention
Last updated Jun 27, 2026 13:01 UTC
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Counseling program aims to boost mental health and HIV prevention in young women
Symptom relief CompletedThis study tested a counseling program called Youth Friendship Bench SA for young women aged 18-25 in South Africa who had symptoms of depression, anxiety, or stress. The program included individual and group counseling sessions, plus optional text reminders. The goal was to see …
Phase: NA • Sponsor: University of California, San Francisco • Aim: Symptom relief
Last updated Jun 28, 2026 00:00 UTC
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Online group therapy helps workers with depression get back on the job
Symptom relief CompletedThis study tested an online group program called Healthy Minds for people on sick leave due to depression, anxiety, or adjustment disorders. 123 participants either joined the 8-week program or received standard care. Researchers tracked their return to work, symptoms, and job fu…
Phase: NA • Sponsor: Université du Québec a Montréal • Aim: Symptom relief
Last updated Jun 27, 2026 13:00 UTC
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Video game therapy shows promise for mental health
Symptom relief CompletedThis study tested whether a 4-week program using active video games (exergames) on the Nintendo Switch could help adults with mental illness feel better and stay motivated. Twelve participants were split into two groups: one played exergames, the other continued their usual routi…
Phase: NA • Sponsor: University of Salamanca • Aim: Symptom relief
Last updated Jun 27, 2026 12:35 UTC
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Gym workouts boost recovery in young adults on antipsychotics
Symptom relief CompletedThis study tested whether a 4-month gym exercise program helps young adults (18-35) taking antipsychotic medication for psychosis or mood disorders feel better in their daily lives. 226 participants were randomly assigned to either continue their usual care or add gym workouts. R…
Phase: NA • Sponsor: Rigshospitalet, Denmark • Aim: Symptom relief
Last updated Jun 27, 2026 12:35 UTC
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Online mental health program shows promise for depression
Symptom relief CompletedThis study tested a digital mental health program for adults with depressive symptoms. The program includes nine online modules covering topics like positive thinking, relaxation, and healthy habits. Researchers compared results between people with diagnosed mood disorders and th…
Phase: NA • Sponsor: Chang Hsiu-Ju • Aim: Symptom relief
Last updated Jun 27, 2026 12:23 UTC
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Art as medicine: study tests whether theatre, dance, and music ease depression
Symptom relief CompletedThis study tested whether taking part in art activities like theatre, dance, visual arts, music, or cinema can improve mental health. 541 adults with psychiatric diagnoses were randomly assigned to either an art program or a waitlist. Researchers measured changes in depression an…
Phase: NA • Sponsor: KAVADIA ELENI • Aim: Symptom relief
Last updated Jun 27, 2026 11:03 UTC
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Can peer support groups boost recovery in mental health?
Symptom relief CompletedThis study tested a 10-week peer support program called 'Paths to everyday life' for adults with mental health difficulties. Participants were randomly assigned to either the peer support group plus usual services, or usual services alone. The goal was to see if the program impro…
Phase: NA • Sponsor: Amager Hospital • Aim: Symptom relief
Last updated Jun 27, 2026 09:01 UTC
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Can Man's best friend boost mental health? new study says maybe.
Symptom relief CompletedThis study tested a 10-session dog-assisted therapy program for 60 adults with severe mental illness. The goal was to see if spending time with trained therapy dogs could help participants build positive mental health behaviors like communication and socialization. Researchers me…
Phase: NA • Sponsor: Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau • Aim: Symptom relief
Last updated Jun 27, 2026 07:57 UTC
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Exercise on campus: a new hope for stressed students?
Symptom relief CompletedThis study tested a 6-week supervised physical activity program for university students dealing with mild-to-moderate mental health issues like stress, anxiety, or feeling isolated. Seventeen students took part in group exercise sessions including walking, aerobics, and strength …
Phase: NA • Sponsor: York St John University • Aim: Symptom relief
Last updated Jun 26, 2026 18:21 UTC
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New psychotherapy shows promise for insomnia in mood disorders
Symptom relief CompletedThis study tested a new 8-session psychotherapy called ChronoS in 67 adults with mood disorders (bipolar or depression) and chronic insomnia. The therapy focuses on sleep-wake awareness and habits. Researchers measured changes in insomnia severity using a standard questionnaire. …
Phase: NA • Sponsor: Centre Hospitalier St Anne • Aim: Symptom relief
Last updated Jun 26, 2026 18:11 UTC
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Can peers help others recover? small study tests new program
Knowledge-focused CompletedThis study tested whether a 10-week recovery program, co-led by a peer with mental illness and a professional, is feasible for people with mental illness in Taiwan. Twenty participants completed the program, which focused on recovery concepts, strengths, and goal setting. Researc…
Phase: NA • Sponsor: National Cheng-Kung University Hospital • Aim: Knowledge-focused
Last updated Jun 27, 2026 14:00 UTC
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New web tool aims to get sick healthcare workers back on the job faster
Knowledge-focused CompletedThis study tested a web application called PRATICAdr 2.0, designed to help healthcare workers on sick leave due to common mental disorders like depression or anxiety return to work. The app helps coordinators track progress and improve communication. Researchers compared workers …
Phase: NA • Sponsor: Université du Québec a Montréal • Aim: Knowledge-focused
Last updated Jun 27, 2026 13:00 UTC
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MRI reveals brain differences in violent suicide attempts
Knowledge-focused CompletedThis study used MRI brain scans and computer tasks to understand how people who attempted suicide make decisions. Researchers compared three groups: those who used violent means, those who used non-violent means, and healthy volunteers. The goal was to find brain activity pattern…
Sponsor: Centre Hospitalier Universitaire de Nīmes • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:38 UTC
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AI therapists in training: can computers teach better counseling?
Knowledge-focused CompletedThis study tested whether artificial intelligence (AI) can realistically simulate conversations between a therapist and a person with a mental health problem. Researchers used 520 simulated sessions to see if the AI could follow proper therapy techniques. The goal is to use these…
Phase: NA • Sponsor: University Hospital, Basel, Switzerland • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:36 UTC
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Brain scans and thinking tests aim to unlock secrets of Self-Harm
Knowledge-focused CompletedThis study looked at how thinking skills and brain activity differ in people who self-harm compared to those who don't. Researchers interviewed 316 adults and gave them thinking tests, with some also having brain scans. The goal was to better understand self-harm to help create m…
Sponsor: Region Skane • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:34 UTC
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Peer support after psychiatric stay shows promise in small VA study
Knowledge-focused CompletedThis study tested a program called Recovery Bridge, where trained peer specialists (people with lived experience of mental illness) helped veterans leaving a psychiatric hospital connect to outpatient care and community life. Fifteen veterans took part to see if the program was f…
Phase: NA • Sponsor: VA Office of Research and Development • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:23 UTC
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Heart and mind: new study explores the hidden links between cardiovascular disease and mental illness
Knowledge-focused CompletedThis completed study looked at 400 people with both heart disease and a mental health condition (like depression or anxiety). Researchers used questionnaires, blood tests, and imaging to find shared risk factors and biological markers. The goal was to better understand how these …
Sponsor: Ningbo No. 1 Hospital • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:06 UTC
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Can training reduce stigma in healthcare? new study tests Anti-Bias program
Knowledge-focused CompletedThis study tested whether an anti-stigma training program for healthcare providers improves attitudes toward people with mental illness or substance use problems. About 485 staff and clients from six health centers took part, with three centers receiving the training and three no…
Phase: NA • Sponsor: Centre for Addiction and Mental Health • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:06 UTC
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Sleep struggles widespread in psychiatric wards
Knowledge-focused CompletedThis study looked at how often insomnia occurs in people hospitalized for psychiatric conditions. Researchers checked 427 patients at 11 hospitals in Switzerland and Germany. They also explored whether age, gender, or type of disorder made insomnia more likely.
Sponsor: University of Bern • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:03 UTC
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Job support program shows promise for mental health recovery
Knowledge-focused CompletedThis study tested a program called IPS-MA, which helps people with mood or anxiety disorders find and keep jobs or return to school. 326 adults who were unable to work within three months took part. The goal was to see if this support, added to their usual treatment, helped them …
Phase: NA • Sponsor: Amager Hospital • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:02 UTC
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Can doing meaningful activities boost recovery in mental illness? new study says maybe.
Knowledge-focused CompletedThis study tested an 8-month program called 'Meaningful Activities and Recovery' (MA&R) for people with mental illness. The program helps people take part in activities that matter to them. 139 adults took part to see if the program improves activity engagement, recovery, and qua…
Phase: NA • Sponsor: Amager Hospital • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:01 UTC
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Can a training program help therapy interns talk better with patients?
Knowledge-focused CompletedThis study tested a program called iCOT to improve how occupational therapy interns communicate with patients in mental health settings. The program included online training and feedback from patients, supervisors, and experts. Researchers compared interns who received iCOT to da…
Phase: NA • Sponsor: Chang Gung Memorial Hospital • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:10 UTC
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Did a simple phone call keep chronic patients out of the hospital?
Knowledge-focused CompletedThis study tested whether a systematic phone call from a medical student, supervised by a general practitioner, could reduce hospitalizations in patients with chronic heart or mental health conditions during the COVID-19 lockdown in France. Over 22,000 patients aged 70 and older …
Phase: NA • Sponsor: University Hospital, Tours • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:07 UTC
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Study aims to make mental health support for kids more efficient and affordable
Knowledge-focused CompletedThis study tested different parts of a family navigation program to see which ones work best for helping low-income and minority families get mental health services for their children. 312 children aged 3-12 who showed signs of behavioral health concerns took part. The goal was t…
Phase: NA • Sponsor: Boston Medical Center • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:00 UTC
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AI could revolutionize online therapy by predicting who benefits most
Knowledge-focused CompletedThis study used artificial intelligence to predict how engaged people would be in online therapy and how much their symptoms would improve. Researchers analyzed data from over 6,600 adults who took part in a digital psychotherapy program. The goal was to create fair and accurate …
Sponsor: University Hospital, Basel, Switzerland • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:57 UTC
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New app aims to boost college success for veterans with mental health struggles
Knowledge-focused CompletedThis study created and tested a mobile app called VetEd for student veterans dealing with mental health issues like depression, PTSD, or anxiety. The goal was to help them manage academics, mental health, and find resources. Researchers worked with 13 veterans to see if the app w…
Phase: NA • Sponsor: VA Office of Research and Development • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:56 UTC
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Hidden ADHD: study reveals how many adults are undiagnosed
Knowledge-focused CompletedThis completed study looked at 224 adults who already had at least one psychiatric condition to see how many also had undiagnosed ADHD. Researchers measured how often ADHD was missed and tracked quality of life in those diagnosed. The goal is to highlight the need for better dete…
Sponsor: Takeda • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:54 UTC
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Therapist connection may boost sleep therapy success
Knowledge-focused CompletedThis study looked at 48 adults with mood disorders and insomnia to see if a strong relationship with their therapist helped them get better results from a new type of therapy called ChronoS. The therapy combines sleep scheduling, mindfulness, and stress management. Researchers me…
Phase: NA • Sponsor: Centre Hospitalier St Anne • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:52 UTC
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Could Low-Nicotine smokes plus E-Cigs cut harm for mentally ill smokers?
Knowledge-focused CompletedThis study looked at whether using very low nicotine cigarettes along with nicotine-containing e-cigarettes can reduce harmful chemical exposure in smokers with mental health conditions. 88 participants were assigned to different combinations of cigarettes and e-cigarettes. The m…
Phase: NA • Sponsor: Milton S. Hershey Medical Center • Aim: Knowledge-focused
Last updated Jun 26, 2026 15:59 UTC