Macrophage activation syndrome
MONDO:0015545A complication of rheumatic disease that is caused by excessive activation and uncontrolled proliferation of T lymphocytes and well-differentiated macrophages. It is characterized by fever, pancytopenia, liver insufficiency, coagulopathy and neurologic symptoms.
Also known as: MAS, reactive hemophagocytic lymphohistiocytosis
13 clinical trials for this condition and its sub-types.
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Can a cancer drug tame a dangerous immune storm?
Disease control Recruiting nowThis early study tests the drug ruxolitinib for a rare but serious condition called IEC-HS, which can happen after CAR-T therapy for cancer. The condition causes a dangerous overreaction of the immune system. The trial will include 16 adults and aims to see if the drug is safe an…
Phase: PHASE1 • Sponsor: Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins • Aim: Disease control
Last updated Jul 30, 2026 00:00 UTC
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New drug targets Life-Threatening immune storm in rheumatic patients
Disease control Recruiting nowThis phase 3 trial tests a drug called plonmarlimab in 30 adults with a severe immune overreaction (macrophage activation syndrome) linked to rheumatic diseases that hasn't responded to prior treatment. Participants receive weekly IV infusions for 8 weeks. The main goal is to see…
Phase: PHASE3 • Sponsor: TJ Biopharma Co., Ltd. • Aim: Disease control
Last updated Jul 22, 2026 00:00 UTC
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Blood test may unlock mystery of Similar-Looking diseases
Diagnosis Recruiting nowThis study is looking for a better way to diagnose three serious conditions that can look alike: Still's disease, sepsis, and macrophage activation syndrome. Researchers will measure a specific form of a blood protein called glycosylated ferritin in 60 people suspected of having …
Sponsor: Brugmann University Hospital • Aim: Diagnosis
Last updated Jun 27, 2026 07:54 UTC
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Researchers launch study to unravel mysteries of rare immune disorder sHLH
Knowledge-focused Recruiting nowThis study aims to understand why some adults develop secondary hemophagocytic lymphohistiocytosis (sHLH), a serious immune condition causing fevers and organ damage. Researchers will follow 300 participants for up to 3 years, collecting blood samples and medical data to identify…
Sponsor: National Institute of Allergy and Infectious Diseases (NIAID) • Aim: Knowledge-focused
Last updated Jun 27, 2026 11:03 UTC
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Tick-Borne mystery: alsace study digs into rare anaplasmosis cases
Knowledge-focused Recruiting nowThis study collects information from about 100 adults in Alsace who have had a confirmed case of human anaplasmosis, a bacterial infection spread by ticks. Researchers want to learn more about how common it is, what symptoms people have, and how serious it can be. The goal is to …
Sponsor: University Hospital, Strasbourg, France • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:07 UTC