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Macrophage activation syndrome

MONDO:0015545

A complication of rheumatic disease that is caused by excessive activation and uncontrolled proliferation of T lymphocytes and well-differentiated macrophages. It is characterized by fever, pancytopenia, liver insufficiency, coagulopathy and neurologic symptoms.

Also known as: MAS, reactive hemophagocytic lymphohistiocytosis

20 clinical trials for this condition and its sub-types.

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Broader categories

Disease (618) Immune system disorder (140) Hemophagocytic syndrome (35) Lymphatic system disorder (27) Syndromic disease (24) Human disease (14) Secondary hemophagocytic lymphohistiocytosis (14) Lymphoid system disorder (1) Disease by body system or component (0)
Trials to join now! 10 Not yet recruiting 1 Not yet finished but already full! 4 Completed 5
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  • New study aims to uncover hidden danger in kawasaki disease

    Knowledge-focused Not yet recruiting

    This study will observe 150 children with Kawasaki disease to learn more about a rare but serious complication called Macrophage Activation Syndrome (MAS). Researchers will collect data on symptoms, lab results, and treatments across multiple European hospitals. The goal is to be…

    Sponsor: Meyer Children's Hospital IRCCS • Aim: Knowledge-focused

    Last updated Jun 27, 2026 12:00 UTC

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