Lipodystrophy
MONDO:0006573A congenital or acquired disorder characterized by abnormal loss or redistribution of the adipose tissue in the body.
Also known as: lipodsystrophic syndrome, lipodsystrophic syndromes, lipodystrophy, lipodystrophy (disease)
48 clinical trials for this condition and its sub-types, 30 tagged with Lipodystrophy itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
Browse by category →Sub-types of Lipodystrophy
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Partial lipodystrophy 7 trials · 19 incl. sub-types
2 sub-types
- Familial partial lipodystrophy 13 trials · 14 incl. sub-types Sub-types →
- Acquired partial lipodystrophy 6 trials
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Hereditary lipodystrophy 2 trials · 17 incl. sub-types
11 sub-types
- Familial partial lipodystrophy 13 trials · 14 incl. sub-types Sub-types →
- Congenital generalized lipodystrophy 2 trials · 3 incl. sub-types Sub-types →
- Berardinelli-Seip congenital lipodystrophy 0 trials · 1 incl. sub-types Sub-types →
- Keppen-Lubinsky syndrome 0 trials
- SHORT syndrome 0 trials
- Wiedemann-Rautenstrauch syndrome 0 trials
- Lipoatrophy with diabetes, leukomelanodermic papules, liver steatosis, and hypertrophic cardiomyopathy 0 trials
- Lipodystrophy due to peptidic growth factors deficiency 0 trials
- Lipodystrophy-intellectual disability-deafness syndrome 0 trials
- Mandibuloacral dysplasia 0 trials Sub-types →
- Severe neurodegenerative syndrome with lipodystrophy 0 trials
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Generalized lipodystrophy 8 trials · 11 incl. sub-types
2 sub-types
- Congenital generalized lipodystrophy 2 trials · 3 incl. sub-types Sub-types →
- Acquired generalized lipodystrophy 0 trials
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Acquired lipodystrophy 3 trials · 9 incl. sub-types
2 sub-types
- Acquired partial lipodystrophy 6 trials
- Acquired generalized lipodystrophy 0 trials
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Localized lipodystrophy 0 trials · 4 incl. sub-types
5 sub-types
- Drug-induced localized lipodystrophy 2 trials
- Centrifugal lipodystrophy 1 trial
- Panniculitis and localized lipodystrophy 1 trial
- Idiopathic localized lipodystrophy 0 trials
- Pressure-induced localized lipoatrophy 0 trials
Most studied deeper sub-types
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Hope for rare fat disorder: drug keeps working in Long-Term study
Disease control OngoingThis study gives the drug metreleptin to 29 people with partial lipodystrophy, a rare condition that causes high blood fats and diabetes. Participants have already shown improvement from the drug in earlier studies. The goal is to keep providing the treatment and check its long-t…
Phase 2 • Sponsor: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) • Aim: Disease control
Last updated Sep 18, 2026 00:00 UTC
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Lifesaving drug made available for rare fat disorder patients
Disease control OngoingThis study gives the drug metreleptin to people with generalized lipodystrophy, a rare condition that causes severe fat loss and leads to high blood fats and diabetes. Participants, aged 6 months and older, have already received metreleptin in past NIH studies but cannot get it i…
Phase 3 • Sponsor: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) • Aim: Disease control
Last updated Sep 18, 2026 00:00 UTC
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Can a hormone replacement tame diabetes and high fats in lipodystrophy?
Disease control Expanded access (ended)This expanded access program provides metreleptin, a synthetic version of the hormone leptin, to people with lipodystrophy who also have diabetes or very high triglycerides. The goal is to see if replacing leptin can help improve blood sugar and fat levels in this rare condition.…
Sponsor: Bristol-Myers Squibb • Aim: Disease control
Last updated Aug 23, 2026 00:00 UTC
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Could a diabetes drug shrink dangerous belly fat in HIV patients?
Disease control OngoingThis study tests whether semaglutide, a drug used for diabetes, can reduce harmful belly fat and improve heart health in people with HIV who have excess fat around the midsection (lipohypertrophy). About 108 participants will receive either semaglutide or a placebo for 32 weeks. …
Phase 2 • Sponsor: Case Western Reserve University • Aim: Disease control
Last updated Jun 27, 2026 12:29 UTC