Lip and oral cavity carcinoma

This phase II trial tests a combination of two drugs—SYS6026 and Enlonstobart—in people with advanced solid tumors that have spread and are linked to HPV types 16 or 18. The study aims to see if the combination is safe and shows signs of shrinking tumors. Participants must be at …

This study tests whether a mixed reality system, similar to video game technology, can help surgeons remove oral cancer and rebuild the area more accurately. Thirty people with oral cancer will be split into three groups: one using mixed reality, one using a virtual surgical guid…

This study tests a low-cost approach to treat pre-cancerous and cancerous mouth lesions using a drug (5-ALA) that makes abnormal cells sensitive to light, followed by laser light delivered through a handheld device. The goal is to destroy these lesions without surgery. The trial …

This Phase 3 trial tests whether giving a short course of targeted radiation (SBRT) followed by chemotherapy and immunotherapy before surgery can improve outcomes for people with advanced oral or HPV-negative throat cancer. About 184 participants will be randomly assigned to rece…

This study tests whether an AI-powered physiotherapy system can help oral cancer patients improve mouth, neck, and shoulder movement after surgery or radiation. Fifteen participants will use the system for 4 to 6 weeks, doing daily exercises prescribed by the AI. The goal is to s…

This study tests whether rinsing with hydrogen water can reduce mouth inflammation and pain in people recovering from oral cancer surgery that used a free flap reconstruction. Thirty-six participants will use hydrogen water or plain water for oral care over 7 days. Researchers wi…

This study tests whether a mobile app with swallowing exercises can help people with oral cancer recover better after reconstructive surgery. About 72 adults in Taiwan will either get standard care or standard care plus the app. Researchers will measure swallowing function, anxie…

This early-phase trial is testing whether injecting a fluorescently labeled version of the immunotherapy drug nivolumab directly into head and neck tumors is safe and helps visualize the tumor and nearby lymph nodes during surgery. Adults with head and neck squamous cell carcinom…

This study looks at how certain cancers develop in people with HIV and what factors might increase their risk. Researchers will analyze medical data from 1,000 HIV-positive adults to track which types of cancer occur most often and why. The goal is to improve early detection and …

This study will test whether a device called the Hypotension Prediction Index (HPI) can help doctors keep blood pressure stable during oral cancer surgery. About 100 adults having oral cancer surgery with flap reconstruction will take part. Half of the surgeries will use the HPI …

This study will measure tongue strength and biting force in 40 mouth cancer patients who use a special plate called an obturator to help them swallow. Researchers want to see how these measurements relate to what patients eat each day. The goal is to better understand how to impr…

This study tests a culturally tailored communication tool to help dentists discuss oral and pharyngeal cancers with Black men. Researchers will train dental providers and then pilot the tool in community settings with 50 Black men. The goal is to see if the tool improves comfort,…