LCAT deficiency
MONDO:0018999LCAT (lecithin-cholesterol acyltransferase) deficiency is a rare lipoprotein metabolism disorder characterized clinically by corneal opacities, and sometimes renal failure and hemolytic anemia, and biochemically by severely reduced HDL cholesterol.
Also known as: lecithin-cholesterol acyltransferase deficiency
4 clinical trials for this condition and its sub-types.
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Broader categories
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One patient gets experimental enzyme to fight rare kidney disease
Disease control CompletedThis study tested an artificial version of the LCAT enzyme (ACP-501) in one person with familial LCAT deficiency, a rare genetic condition that leads to low 'good' cholesterol and kidney failure. The participant received several infusions of the drug over weeks, with regular bloo…
Sponsor: National Heart, Lung, and Blood Institute (NHLBI) • Aim: Disease control
Last updated Sep 03, 2026 00:00 UTC
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Could a 5:2 diet melt fat from your liver?
Disease control CompletedThis study looked at whether an 8-week 5:2 intermittent fasting diet could help people with fatty liver disease. Eighty adults with excess liver fat followed the diet, eating normally for 5 days and restricting calories to 500 kcal on 2 non-consecutive days each week. Researchers…
Sponsor: Beijing Chao Yang Hospital • Aim: Disease control
Last updated Jun 27, 2026 07:51 UTC