Laryngeal squamous cell carcinoma

This trial tests whether a combination of the immunotherapy drug pembrolizumab, chemotherapy, and radiation can control advanced larynx cancer while preserving the voice box. Adults with stage III or IV larynx cancer who are candidates for organ preservation receive three cycles …

This pilot study tests whether injecting a corticosteroid called dexamethasone directly into the salivary glands can prevent dry mouth in people receiving radiation therapy for head and neck cancer. Researchers will enroll 10 adults with certain types of throat cancer who are sch…

This study tested whether giving the immunotherapy drug durvalumab alongside radiation works better than the standard cetuximab plus radiation for people with advanced head and neck cancer who cannot take the usual chemotherapy drug cisplatin. A total of 196 adults took part. The…

This study tested whether giving lower doses of radiation after surgery for head and neck cancer could reduce long-term side effects like dry mouth and trouble swallowing, while still keeping the cancer from coming back. About 200 patients with certain stages of oral, throat, or …

This study tested whether combining two FDA-approved cancer drugs, cetuximab and nivolumab, could help people with advanced head and neck cancer that has returned or spread. A total of 95 participants received the drug combination to find the best dose and see if it improves surv…

This phase II trial tested whether adding sorafenib to cetuximab works better than cetuximab alone for patients with advanced head and neck cancer that has come back or spread. Fifty-five adults with various types of head and neck cancer took part. The study measured how long pat…

This study tested a new way to give radiation for head and neck cancer. Instead of treating the whole neck, doctors used artificial intelligence to focus radiation only on the cancer spots. 67 patients took part to see if this approach could reduce side effects without increasing…

This early-phase trial tested a combination of two drugs — IRX-2 and durvalumab — in 19 people with advanced head and neck cancer that could not be cured by standard treatments. The goal was to see if the combination was safe and could boost the immune response inside tumors. The…

This phase II trial tested whether adding the targeted drug cetuximab to standard chemotherapy and radiation could help prevent head and neck cancer from coming back after surgery. The study enrolled 53 patients with certain high-risk features. The main goal was to see how many p…

This study tested a new type of radiation therapy that adjusts the treatment beam each day based on the patient's current anatomy. The goal was to see if this daily adaptive approach could reduce chronic dry mouth (xerostomia) compared to standard radiation in 50 people with head…

Researchers are studying blood and tumor tissue from people with squamous cell cancer of the larynx, pharynx, or oral cavity who have no history of smoking, heavy drinking, or workplace exposure to substances like asbestos or wood dust. The goal is to learn how DNA changes and bi…

This study followed 240 people with head and neck cancer to see how their swallowing changed from diagnosis to 18 months after their first treatment. Researchers used a questionnaire called the Deglutition Handicap Index (DHI) to measure patients' own experience of swallowing pro…