Laryngeal neoplasm

This study tested whether giving the immunotherapy drug durvalumab alongside radiation works better than the standard cetuximab plus radiation for people with advanced head and neck cancer who cannot take the usual chemotherapy drug cisplatin. A total of 196 adults took part. The…

This trial tests two aggressive radiation therapy schedules for people with advanced head and neck cancer that cannot be removed with surgery. One approach uses a very intense radiation schedule combined with chemotherapy, while the other uses a very accelerated radiation schedul…

This study tested a combination of two drugs, pembrolizumab and cetuximab, in 78 people with advanced head and neck cancer that had returned or spread. The goal was to see if the combination could shrink tumors or slow the disease. Participants were grouped based on whether they …

This early-phase study tested a special artificial larynx with valves in 10 adults who had severe swallowing troubles, often after throat cancer. The goal was to see if the device could help them swallow safely and possibly allow them to close their tracheotomy tube. The study fo…

This study looked at 65 people with advanced head and neck cancer that had spread to lymph nodes. It compared two approaches: having surgery to remove affected lymph nodes before chemo-radiation, versus chemo-radiation alone. The goal was to see if upfront surgery could reduce tr…

This study tested whether placing a flap of neck tissue over the closure line after total larynx removal (laryngectomy) could lower the chance of a pharyngocutaneous fistula—an abnormal opening that can leak saliva and delay healing. Fifty patients with advanced laryngeal cancer …

This early-phase trial tested whether adding the immunotherapy drug pembrolizumab to standard chemoradiation is safe and effective for people with advanced head and neck cancer. 59 participants received pembrolizumab before, during, and after their regular treatment. The goal was…

This study tests whether a program combining resistance training and a Mediterranean diet is practical and helpful for people with head and neck cancer undergoing radiation. Forty participants will receive supervised exercise sessions and pre-made meals, plus dietary coaching. Th…

This study looked at whether acupuncture can reduce dry mouth (xerostomia) caused by radiation therapy in people with head and neck cancer. A total of 258 participants were randomly assigned to receive acupuncture or usual care. The main goal was to see if acupuncture improved dr…

This study tested a digital platform designed to help patients recover physically and mentally after major surgery for esophageal or laryngeal cancer. The platform offered short daily exercise sessions. The study included 30 patients and focused on whether they would use the tool…

This completed study tested whether a new biomarker called 'mass response' can predict how well a cancer therapy will work. Researchers collected tumor cells from 72 patients with various cancers through fluid drainage or biopsies. The goal was to see if this biomarker could guid…

This study looked at how people who had their voice box removed due to throat cancer produce a new voice. Researchers used a special high-speed camera to record vibrations in the throat and compared them to sound recordings. The goal was to better understand these substitute voic…

This study looked at 100 adults with irregular patches on their vocal cords. Researchers used a special camera called a laryngostroboscope to see how the vocal cords vibrate, then compared those results with standard tissue analysis. The goal was to see if the camera test alone c…

This study looked at how well robot-assisted surgery removes early-stage laryngeal cancer. 54 patients had their tumors removed using a da Vinci robot. The main goal was to see how often the surgery got all the cancer out (clear surgical margins). The study also tracked surgery t…

This study tested two types of pictorial warning labels on alcohol to see which better communicates cancer risks. Over 1,000 adults who drink regularly viewed labels with either personal stories (narrative) or images of diseased organs (non-narrative). Researchers measured attent…

This completed study tested a French version of a swallowing questionnaire for people who had their throat and voice box removed due to cancer. Researchers wanted to see if the translated survey works well for French-speaking patients. The study involved 225 adults who could read…