Infectious disease with sepsis

This study looks at whether giving steroids very early to patients with severe infections and low blood pressure works better than waiting until standard treatments fail. About 230 adults will be randomly assigned to get either early steroids or a placebo, and neither they nor th…

This early-phase trial tested whether inhaling low doses of carbon monoxide could be safe for people with severe lung injury caused by sepsis. Only 5 participants were enrolled before the study was stopped early. The goal was to see if a personalized dosing formula could safely a…

This study tested whether using a urine biomarker test (NephroCheck) to guide treatment could reduce kidney injury, dialysis, or death in sepsis patients. The trial planned to enroll many participants but was stopped early after only 19 people joined. The idea was to catch kidney…

This phase 3 trial tested whether the antiviral drug ganciclovir could prevent reactivation of cytomegalovirus (CMV) in adults with sepsis who needed a breathing machine. The study enrolled 205 CMV-positive patients in the ICU with acute respiratory failure. Participants received…

This study tests whether a standard blood test can help predict sepsis in adults arriving at the emergency department. The test measures a marker called monocyte distribution width (MDW), which reflects how varied certain white blood cells are. Researchers will compare MDW result…

This study looked at whether changes in gene activity in blood cells can help doctors tell the difference between a normal inflammatory response after major surgery and a serious infection. Researchers planned to enroll 61 adults undergoing high-risk noncardiac surgery. The study…