In situ carcinoma
MONDO:0004647A malignant epithelial neoplasm which is confined to the epithelial layer without evidence of further tissue invasion.
Also known as: CIS, carcinoma in situ, carcinoma, in situ, malignant, epithelial tumor, in situ, malignant, intraepithelial carcinoma, non-invasive carcinoma, stage 0 disease
3066 clinical trials for this condition and its sub-types, 25 tagged with In situ carcinoma itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
Browse by category →Sub-types of In situ carcinoma
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Breast carcinoma in situ 76 trials · 204 incl. sub-types
4 sub-types
- Ductal breast carcinoma in situ 152 trials Sub-types →
- Lobular neoplasia 4 trials · 30 incl. sub-types Sub-types →
- Ductal breast carcinoma in situ and lobular carcinoma in situ 1 trial
- Breast apocrine carcinoma in situ 0 trials
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Adenocarcinoma in situ 10 trials · 170 incl. sub-types
3 sub-types
- Ductal breast carcinoma in situ 152 trials Sub-types →
- Lobular breast carcinoma in situ 27 trials
- Lung adenocarcinoma in situ 1 trial
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Bladder carcinoma in situ 30 trials
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Intestine carcinoma in situ 0 trials · 16 incl. sub-types
2 sub-types
- Rectum carcinoma in situ 1 trial · 13 incl. sub-types Sub-types →
- Colon carcinoma in situ 3 trials Sub-types →
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Uterus carcinoma in situ 0 trials · 16 incl. sub-types
2 sub-types
- Uterine cervix carcinoma in situ 15 trials
- Endometrium carcinoma in situ 1 trial
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Esophagus carcinoma in situ 13 trials
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Squamous carcinoma in situ 5 trials · 10 incl. sub-types
3 sub-types
- Skin squamous cell carcinoma in situ 4 trials · 6 incl. sub-types Sub-types →
- Penis carcinoma in situ 1 trial
- Trachea carcinoma in situ 0 trials
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Skin carcinoma in situ 3 trials · 9 incl. sub-types
1 sub-type
- Skin squamous cell carcinoma in situ 4 trials · 6 incl. sub-types Sub-types →
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Oral cavity carcinoma in situ 5 trials
1 sub-type
- Lip carcinoma in situ 0 trials
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Stomach carcinoma in situ 4 trials
3 sub-types
- Carcinoma in situ of fundus of stomach 0 trials
- Carcinoma in situ of gastric body 0 trials
- Carcinoma in situ of gastric cardia 0 trials
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Lung carcinoma in situ 2 trials · 3 incl. sub-types
2 sub-types
- Lung adenocarcinoma in situ 1 trial
- Bronchus carcinoma in situ 0 trials
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Pharynx carcinoma in situ 0 trials · 2 incl. sub-types
3 sub-types
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Larynx carcinoma in situ 1 trial
1 sub-type
- Carcinoma in situ of epiglottis 0 trials
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Carcinoma in situ of ureter 0 trials
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Carcinoma in situ of urethra 0 trials
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Eye carcinoma in situ 0 trials
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Gall bladder carcinoma in situ 0 trials
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Kidney carcinoma in situ 0 trials
1 sub-type
- Carcinoma in situ of renal pelvis 0 trials
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Liver carcinoma in situ 0 trials
1 sub-type
- Bile duct carcinoma in situ 0 trials Sub-types →
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Nasal cavity carcinoma in situ 0 trials
Most studied deeper sub-types
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New vaccine-like therapy aims to keep bladder cancer from coming back
Disease control Recruiting nowThis study tests whether adding an experimental treatment (V940) to standard BCG therapy helps people with high-risk non-muscle invasive bladder cancer live longer without their cancer returning. About 308 adults will be randomly assigned to get either V940 plus BCG or BCG alone.…
Phase 2 • Sponsor: Merck Sharp & Dohme LLC • Aim: Disease control
Last updated Sep 16, 2026 00:00 UTC
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New bladder cancer therapy shows promise in early trial
Disease control Recruiting nowThis phase 2 study is testing a new treatment called TARA-002 for people with a type of high-grade bladder cancer that hasn't spread into the muscle. The treatment is given directly into the bladder through a catheter once a week for 6 weeks. The study will include about 131 adul…
Phase 2 • Sponsor: Protara Therapeutics • Aim: Disease control
Last updated Aug 26, 2026 00:00 UTC
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New bladder cancer drug TARA-002 faces chemotherapy in major trial
Disease control Recruiting nowThis phase 3 trial tests whether a new drug, TARA-002, works better than standard chemotherapy for a type of early-stage bladder cancer. About 284 adults who have not received BCG therapy will be randomly assigned to receive either TARA-002 or chemotherapy directly into the bladd…
Phase 3 • Sponsor: Protara Therapeutics • Aim: Disease control
Last updated Aug 23, 2026 00:00 UTC
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New Gene-Based bladder cancer treatment shows promise in early trial
Disease control Recruiting nowThis study tests a new drug called EG-70 (detalimogene) for a type of bladder cancer called non-muscle invasive bladder cancer (NMIBC). The drug is given directly into the bladder through a catheter. The trial includes patients whose cancer did not respond to standard BCG therapy…
Phase 1/2 • Sponsor: enGene, Inc. • Aim: Disease control
Last updated Aug 09, 2026 00:00 UTC
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New virus therapy takes on tough bladder cancer
Disease control Recruiting nowThis phase 2 trial is testing a treatment called cretostimogene grenadenorepvec, a modified virus designed to infect and destroy cancer cells, in 16 people with high-risk bladder cancer that has not responded to standard BCG therapy. The study aims to see if the treatment can mak…
Phase 2 • Sponsor: Lepu Biopharma Co., Ltd. • Aim: Disease control
Last updated Jun 27, 2026 12:23 UTC
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Bladder cancer patients may avoid surgery with new drug combo
Disease control Recruiting nowThis phase 2 trial is testing whether two chemotherapy drugs, gemcitabine and docetaxel, given directly into the bladder can treat high-risk bladder cancer that did not respond to standard BCG therapy. About 174 adults will receive weekly treatments for 6 weeks, then monthly for …
Phase 2 • Sponsor: Michael A. O'Donnell • Aim: Disease control
Last updated Jun 27, 2026 12:09 UTC
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New Tumor-Injected drug shows promise in early cancer trial
Disease control Recruiting nowThis early-stage trial tests a new drug called ONM-501, which is injected directly into tumors, either alone or with the immunotherapy cemiplimab (Libtayo). The study includes 168 adults with advanced solid tumors or lymphomas that have not responded to standard treatments. The m…
Phase 1 • Sponsor: OncoNano Medicine, Inc. • Aim: Disease control
Last updated Jun 27, 2026 08:06 UTC
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Voice showdown: laser vs. radiation for early throat cancer
Disease control Recruiting nowThis study compares two standard treatments for early-stage larynx cancer: laser surgery and a newer, more precise radiation therapy that targets only the affected vocal cord. The main goal is to see which approach better preserves voice quality over two years. About 34 adults wi…
Sponsor: Olgun Elicin • Aim: Disease control
Last updated Jun 27, 2026 07:53 UTC
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Can special workouts help breast cancer survivors regain muscle?
Symptom relief Recruiting nowThis study compares two standard exercise programs to see which one better helps women increase muscle mass after breast cancer treatment. Thirty women aged 20-89 who have completed treatment (except chemotherapy) will follow either standard resistance training or a special 6-12-…
Sponsor: Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute) • Aim: Symptom relief
Last updated Jun 27, 2026 09:01 UTC
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Massive childhood cancer registry launches to unlock better treatments
Knowledge-focused Recruiting nowThis study is a large registry that collects health information and leftover tumor or blood samples from up to 75,000 children and young adults with cancer. The goal is to track outcomes and gather data to help doctors find better ways to treat and care for these patients over ti…
Sponsor: Children's Oncology Group • Aim: Knowledge-focused
Last updated Aug 27, 2026 00:00 UTC
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Can we spot cancer before it starts? a massive study aims to find out
Knowledge-focused Recruiting nowThis study is building a large collection of blood, saliva, urine, stool, and tissue samples from people who are at increased risk of cancer, including those with genetic predispositions, survivors of childhood or adult cancer, or those with precancerous conditions. The goal is t…
Sponsor: Dana-Farber Cancer Institute • Aim: Knowledge-focused
Last updated Aug 19, 2026 00:00 UTC
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Small study aims to predict how Barrett's esophagus responds to heat therapy
Knowledge-focused Recruiting nowThis study looks at how the esophagus changes in people with a precancerous condition called Barrett's esophagus who are getting a treatment called radiofrequency ablation (RFA). Researchers will use two special devices during routine endoscopies to measure the tightness and heal…
Sponsor: Mayo Clinic • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:02 UTC