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Immune-mediated necrotizing myopathy

MONDO:0016098

Necrotizing autoimmune myopathy (NAM) is a rare form of idiopathic inflammatory myopathy characterized clinically by acute or subacute proximal muscle weakness, and histopathologically by myocyte necrosis and regeneration without significant inflammation.

Also known as: IMNM, NAM, anti-HMG-CoA myopathy, anti-SRP myopathy, autoimmune necrotizing myositis, immune myopathy with myocyte necrosis, necrotizing autoimmune myopathy

66 clinical trials for this condition and its sub-types.

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Broader categories

Disease (618) Inflammatory disease (310) Musculoskeletal system disorder (196) Myositis disease (94) Acquired idiopathic inflammatory myopathy (61) Muscle tissue disorder (53) Idiopathic inflammatory myopathy (52) Human disease (14) Myopathy (11) Skeletal muscle disorder (8)

Trials to join now! 31 Not yet recruiting 10 Not yet finished but already full! 11 Completed 13 Terminated 1

Scientists gather leftover surgical tissue to unlock secrets of bone disease

Knowledge-focused Terminated

This study collected bone, cartilage, skin, and fat tissue from 50 patients undergoing surgery at Children's National Medical Center. The goal was to grow cells from these tissues in the lab and analyze them to better understand bone and connective tissue diseases. The study was …

Sponsor: National Institute of Dental and Craniofacial Research (NIDCR) • Aim: Knowledge-focused

Last updated Jun 27, 2026 07:52 UTC