Immune-mediated necrotizing myopathy
MONDO:0016098Necrotizing autoimmune myopathy (NAM) is a rare form of idiopathic inflammatory myopathy characterized clinically by acute or subacute proximal muscle weakness, and histopathologically by myocyte necrosis and regeneration without significant inflammation.
Also known as: IMNM, NAM, anti-HMG-CoA myopathy, anti-SRP myopathy, autoimmune necrotizing myositis, immune myopathy with myocyte necrosis, necrotizing autoimmune myopathy
24 clinical trials for this condition and its sub-types.
Follow this condition — get notified about new trialsBroader categories
-
Can a targeted immune drug calm rare muscle inflammation?
Disease control CompletedThis trial tests whether efgartigimod, an injected drug that blocks certain immune antibodies, can improve muscle strength and function in adults with active idiopathic inflammatory myopathy — a group of rare autoimmune diseases that cause muscle inflammation and weakness. About …
Phase: PHASE2, PHASE3 • Sponsor: argenx • Aim: Disease control
Last updated Jul 26, 2026 00:00 UTC
-
MRI may replace needle biopsy for muscle disease diagnosis
Diagnosis CompletedThis study looked at whether whole body MRI can accurately diagnose inflammatory myopathies—a group of muscle diseases causing weakness and damage. Researchers compared MRI results with muscle biopsies in 139 people suspected of having these conditions. If MRI proves reliable, it…
Phase: NA • Sponsor: Assistance Publique - Hôpitaux de Paris • Aim: Diagnosis
Last updated Jun 27, 2026 12:02 UTC