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IgE responsiveness, atopic
MONDO:0007817Immediate hypersensitivity reaction - type I reaction, involves immunoglobulin E (IgE)-mediated release of chemical mediators from mast cells and basophils. Th2 cells produce IL-4 and IL-13, which then act on B cells to promote the production of antigen-specific IgE. Reexposure to the antigen can then result in the antigen binding to and cross-linking the bound IgE antibodies on the mast cells and basophils. This causes the release of preformed mediators (histamine, tryptase, tryptase, chemotactic factors), newly synthesized mediators (leukotrienes, prostaglandin, thromboxane, platelet-activating factor, adenosine, bradykinin), and cytokines from these cells that results in structural and functional changes to the affected tissue.
Also known as: IgE responsiveness, atopic, IgE, elevated level of, immediate hypersensitivity, type 1 hypersensitivity, type 1 hypersensitivity reaction, type I hypersensitivity, type I hypersensitivity reaction, type I immediate hypersensitivity reaction
17 clinical trials for this condition and its sub-types.
Follow this condition — get notified about new trialsBroader categories
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HPV vaccine shows promise for girls on Immune-Suppressing drugs
⭐️ VACCINE ⭐️ CompletedThis study looked at whether the HPV vaccine works in girls aged 9 to 17 who are taking medicines that weaken their immune system, such as after an organ transplant or for diseases like lupus. The goal was to see if their bodies produce enough antibodies to protect against HPV. T…
Phase: PHASE2 • Sponsor: University Hospital, Bordeaux • Aim: ⭐️ VACCINE ⭐️
Last updated Jun 27, 2026 12:36 UTC
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Which allergy skin prick test hurts least and works best?
Diagnosis CompletedThis study compared three FDA-cleared allergy skin test devices (AllerTest-10, Lincoln Multi-Test II, and Greer Skintestor OMNI) in 30 adults to see which is most accurate and least painful. Participants received histamine and glycerin controls on their skin, and researchers meas…
Phase: NA • Sponsor: QHSLab, Inc. • Aim: Diagnosis
Last updated Jun 27, 2026 09:04 UTC
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Full-Dose drug testing could pinpoint surgery allergies
Diagnosis CompletedThis study tested whether giving full therapeutic doses of anaesthetics like propofol and ketamine can safely diagnose drug allergies in people who had a suspected allergic reaction during surgery. Fifty adult patients with a history of perioperative hypersensitivity underwent in…
Phase: NA • Sponsor: University Hospital, Antwerp • Aim: Diagnosis
Last updated Jun 26, 2026 15:03 UTC
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Could this treatment stop allergies before they start? new study in infants shows promise
Prevention CompletedThis study tested a new treatment called STMC-103H in 283 newborn babies and infants who are at high risk for developing allergies (like eczema or food allergies) because of their family history. The goal was to see if the treatment is safe and can prevent these allergic conditio…
Phase: PHASE1, PHASE2 • Sponsor: Siolta Therapeutics, Inc. • Aim: Prevention
Last updated Jun 27, 2026 07:59 UTC
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Mystery autumn allergies traced to birch rust?
Knowledge-focused CompletedThis study investigates whether spores from birch rust fungi trigger seasonal allergies in autumn. Researchers will compare 30 people with suspected birch rust allergy to 15 non-allergic controls, tracking symptoms and spore levels. The goal is to understand a possible cause of a…
Sponsor: University Hospital of North Norway • Aim: Knowledge-focused
Last updated Jun 27, 2026 14:00 UTC
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New study aims to spot Life-Threatening allergies in the operating room
Knowledge-focused CompletedThis study looked at 145 people who had an allergic or non-allergic reaction during surgery. Researchers wanted to find out which signs, like skin changes or heart rate, could tell the difference between a true allergy and a non-allergic reaction. The goal is to help doctors trea…
Sponsor: Assistance Publique - Hôpitaux de Paris • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:04 UTC
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Scientists probe genetic roots of Cold-Triggered hives
Knowledge-focused CompletedThis study looks at why some people develop hives from physical triggers like cold, pressure, or sunlight. Researchers will test participants' skin reactions and collect blood and genetic samples to understand the role of immune cells and genes. The goal is to uncover the underly…
Sponsor: National Institute of Allergy and Infectious Diseases (NIAID) • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:01 UTC
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Scientists gather clues on mysterious immune defects
Knowledge-focused CompletedThis study collected blood, saliva, stool, urine, and skin samples from 19 people with unknown or poorly understood immune system problems. The goal was to learn how different parts of the immune system work together. No treatments or drugs were tested. Participants were followed…
Sponsor: National Institute of Allergy and Infectious Diseases (NIAID) • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:58 UTC
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New study aims to crack the code on insulin allergies
Knowledge-focused CompletedThis study looks at 55 adults with diabetes who are either allergic to insulin or not, to better understand and diagnose insulin allergy. Researchers will test a step-by-step diagnostic approach and study the immune system's role. The goal is to make it easier to identify the exa…
Phase: NA • Sponsor: Assistance Publique - Hôpitaux de Paris • Aim: Knowledge-focused
Last updated Jun 26, 2026 16:23 UTC