Hypogonadism
MONDO:0002146A disorder characterized by decreased function of the gonads. Clinical manifestations in both males and females include poor libido, infertility, and osteoporosis. Additional signs in males include erectile dysfunction, muscle atrophy, gynecomastia and increased abdominal fat. In females, additional signs include shrinking of the breasts and loss of, or failure to develop menstruation.
Also known as: gonadotropin deficiency, hypogonadotropism
164 clinical trials for this condition and its sub-types, 47 tagged with Hypogonadism itself.
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Sub-types of Hypogonadism
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Hypogonadotropic hypogonadism 19 trials · 100 incl. sub-types
10 sub-types
- Congenital hypogonadotropic hypogonadism 0 trials · 83 incl. sub-types Sub-types →
- Kallmann syndrome 3 trials Sub-types →
- Hypogonadotropic hypogonadism 24 without anosmia 1 trial
- Hypogonadotropic hypogonadism 10 with or without anosmia 0 trials
- Hypogonadotropic hypogonadism 12 with or without anosmia 0 trials
- Hypogonadotropic hypogonadism 13 with or without anosmia 0 trials
- Hypogonadotropic hypogonadism 23 with or without anosmia 0 trials
- Hypogonadotropic hypogonadism 25 with anosmia 0 trials
- Hypogonadotropic hypogonadism 26 with or without anosmia 0 trials
- Hypogonadotropic hypogonadism 27 without anosmia 0 trials
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Gonadal dysgenesis 1 trial · 32 incl. sub-types
5 sub-types
- Turner syndrome 29 trials Sub-types →
- 46 XX gonadal dysgenesis 1 trial Sub-types →
- 46,XY complete gonadal dysgenesis 0 trials · 1 incl. sub-types Sub-types →
- 45,X/46,XY mixed gonadal dysgenesis 0 trials
- Testicular dysgenesis syndrome 0 trials
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Hypogonadism, male 24 trials
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Eunuchism 16 trials
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Slti-Salem syndrome 0 trials
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Weinstein kliman scully syndrome 0 trials
Most studied deeper sub-types
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New nasal spray aims to curb relentless hunger in rare genetic disorder
Disease control Stopped earlyThis study tests the long-term safety of a nasal spray called carbetocin for people with Prader-Willi syndrome who experience severe, constant hunger (hyperphagia). About 160 participants who completed a previous study will receive the spray three times daily. The goal is to see …
Phase 3 • Sponsor: ACADIA Pharmaceuticals Inc. • Aim: Disease control
Last updated Aug 19, 2026 00:00 UTC
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New hope for rare hunger disorder: drug shows promise in Long-Term trial
Disease control Stopped earlyThis study tests whether ARD-101 can safely reduce extreme hunger and food-related behaviors in people with Prader-Willi syndrome over 12 months. About 90 participants who completed a prior study will take the drug daily and visit the clinic regularly. The goal is to improve qual…
Phase 3 • Sponsor: Aardvark Therapeutics, Inc. • Aim: Disease control
Last updated Jul 02, 2026 00:00 UTC
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Can a daily injection reshape bodies of HIV patients?
Disease control Stopped earlyThis study looked at whether tesamorelin (Egrifta), a daily injection that boosts growth hormone, can improve body composition in people with HIV who have excess belly fat (lipodystrophy). Six participants received the drug for up to 12 months, with researchers measuring liver fa…
Phase 4 • Sponsor: Columbia University • Aim: Disease control
Last updated Jun 27, 2026 12:36 UTC
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New oral test could replace painful insulin injections for hormone diagnosis
Diagnosis Stopped earlyThis study tested a new oral drink (GS3-007a) to diagnose adult growth hormone deficiency (AGHD). It compared the drink to the standard insulin tolerance test in 120 adults suspected of having AGHD and healthy volunteers. The goal was to see if the oral test works as well as the …
Phase 2 • Sponsor: Changchun GeneScience Pharmaceutical Co., Ltd. • Aim: Diagnosis
Last updated Jun 27, 2026 12:37 UTC
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Hope for rare hunger disorder: new drug enters final testing phase
Symptom relief Stopped earlyThis phase 3 trial tests whether ARD-101 can reduce the intense, constant hunger (hyperphagia) seen in Prader-Willi syndrome. About 90 participants will take either ARD-101 or a placebo daily for 12 weeks. Caregivers will track changes in hunger-related behaviors using a standard…
Phase 3 • Sponsor: Aardvark Therapeutics, Inc. • Aim: Symptom relief
Last updated Jul 02, 2026 00:00 UTC
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CBDV study for Prader-Willi syndrome halted early
Symptom relief Stopped earlyThis study tested whether a cannabis-derived compound called CBDV could safely reduce irritability in children and young adults with Prader-Willi syndrome. Only 6 people enrolled before the study was stopped early. The goal was to see if CBDV helped with mood and behavior problem…
Phase 2 • Sponsor: Eric Hollander • Aim: Symptom relief
Last updated Jun 27, 2026 12:30 UTC
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Ultrasound could uncover hidden vascular risks in turner syndrome
Knowledge-focused Stopped earlyThis study is looking at whether yearly ultrasound scans can detect blood vessel abnormalities throughout the body in women with Turner syndrome, not just in the heart area. Turner syndrome is a genetic condition that increases the risk of serious vascular problems, which can sho…
Sponsor: University Hospital, Strasbourg, France • Aim: Knowledge-focused
Last updated Aug 23, 2026 00:00 UTC
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Brain and eye clues to emotion recognition in autism and psychosis
Knowledge-focused Stopped earlyThis study aimed to understand why people with autism or schizophrenia sometimes struggle to recognize emotions on faces. Researchers used brain wave recordings (EEG) and eye-tracking to see how participants processed facial expressions. The study included people with autism, sch…
Sponsor: Hôpital le Vinatier • Aim: Knowledge-focused
Last updated Jun 27, 2026 13:07 UTC