Hypersomnia

This Phase 3 study tests whether expanded dosing regimens of Xywav can safely reduce excessive daytime sleepiness in adults with narcolepsy or idiopathic hypersomnia. About 108 participants will receive either Xywav or a placebo in a randomized withdrawal design. The main goal is…

This study tests whether a drug called gamma-hydroxybutyrate (GHB) can help intensive care patients get better deep sleep. Sleep problems are very common in the ICU and can lead to serious issues like confusion and longer recovery. The trial will give GHB or a placebo to 24 adult…

This study tests a slow-release melatonin (PedPRM) in 120 children aged 6 to 18 who have anorexia nervosa and trouble sleeping. Participants take either melatonin or a placebo for 13 weeks. The goal is to see if it safely improves total sleep time and related symptoms like anxiet…

This study looks at whether adding sleep-focused treatments to standard psychiatric care can reduce suicide risk in young adults. About 90 college students with suicidal thoughts and sleep problems will be randomly assigned to one of three sleep interventions. Researchers will tr…

This study will monitor 75 adults—natural short sleepers, normal sleepers, and people with idiopathic hypersomnia—over 32 continuous hours in a sleep lab. Using EEG and actigraphy, researchers will track brain wave patterns and blood sugar changes to understand how the body regul…

This study looks at how the amount of deep sleep just before waking affects how alert people feel after a 2-hour nap taken at night. Researchers will monitor brain activity during sleep and test reaction times after waking. The goal is to understand sleep inertia and improve nap …