Hypersensitivity reaction disease
MONDO:0000605An immune system disease that has basis in dysregulation of the hypersensitivity reaction, an inflammatory response to an exogenous environmental antigen or an endogenous antigen initiated by the adaptive immune system.
Also known as: allergic reaction, sensitive, sensitivity, hypersensitive, hypersensitivity, hypersensitivity reaction
1025 clinical trials for this condition and its sub-types, 32 tagged with Hypersensitivity reaction disease itself.
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Sub-types of Hypersensitivity reaction disease
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Allergic disease 179 trials · 969 incl. sub-types
12 sub-types
- Atopic eczema 468 trials · 481 incl. sub-types Sub-types →
- Allergic respiratory disease 2 trials · 220 incl. sub-types Sub-types →
- Food allergy 115 trials
- Drug allergy 35 trials
- Eye allergy 2 trials · 20 incl. sub-types Sub-types →
- Atopic IgE-mediated allergic disorder 13 trials
- Venom allergy 12 trials
- Gastrointestinal allergy 0 trials · 5 incl. sub-types Sub-types →
- Alpha-gal syndrome 4 trials
- Allergic otitis media 0 trials Sub-types →
- Latex allergy 0 trials
- Vulvovaginitis, allergic seminal 0 trials
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Anaphylaxis 26 trials · 27 incl. sub-types
2 sub-types
- Exercise-induced anaphylaxis 0 trials · 1 incl. sub-types Sub-types →
- Idiopathic anaphylaxis 1 trial
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Type IV hypersensitivity disease 0 trials · 18 incl. sub-types
3 sub-types
- Autoimmune lymphoproliferative syndrome 11 trials · 12 incl. sub-types Sub-types →
- Cryoglobulinemia 3 trials Sub-types →
- Serum sickness 3 trials
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Hypersensitivity vasculitis 0 trials · 16 incl. sub-types
2 sub-types
- Immunoglobulin A vasculitis 16 trials
- Allergic cutaneous vasculitis 1 trial
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IgE responsiveness, atopic 9 trials
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Type III hypersensitivity disease 3 trials · 6 incl. sub-types
2 sub-types
- Serum sickness 3 trials
- Arthus reaction 0 trials
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Progestogen hypersensitivity 3 trials
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Pseudoallergy 0 trials
1 sub-type
- Drug pseudoallergy 0 trials
Most studied deeper sub-types
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New foam aims to soothe immunotherapy skin side effects
Symptom relief Not yet recruitingThis phase 2 trial tests a medicated foam called roflumilast on skin rashes caused by checkpoint inhibitor cancer drugs. Twenty adults with mild to severe rash will apply the foam daily for 16 weeks. The goal is to see if it safely reduces rash severity and improves quality of li…
Phase 2 • Sponsor: Massachusetts General Hospital • Aim: Symptom relief
Last updated Jun 27, 2026 13:07 UTC
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Could a 1-Hour allergy shot replace the 4-Hour wait for emergency CT?
Symptom relief Not yet recruitingThis study tests whether giving a steroid and antihistamine just 1 hour before a CT scan is as safe as the standard 4-hour premedication for people with contrast allergies. It involves 540 emergency department adults who need a CT for a serious condition. If successful, it could …
Sponsor: Paul Peng, MD PhD MSCR • Aim: Symptom relief
Last updated Jun 27, 2026 09:06 UTC
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Simple skin test may prevent chemotherapy allergies
Knowledge-focused Not yet recruitingThis study tests whether a skin test can predict allergic reactions to the chemotherapy drug oxaliplatin. About 380 cancer patients will receive a tiny amount of oxaliplatin under the skin before their regular treatment. Researchers will check if the skin test results match who a…
Sponsor: Fujian Cancer Hospital • Aim: Knowledge-focused
Last updated Jun 27, 2026 13:00 UTC
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Which dressing is kinder to your skin after shoulder surgery?
Knowledge-focused Not yet recruitingThis study looks at how often people develop allergic skin reactions to two different wound dressings used after open shoulder surgery: one made from silk protein and another from a medical glue mesh. About 350 adults having shoulder surgery will be randomly assigned to one dress…
Sponsor: The University of Texas Health Science Center, Houston • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:32 UTC
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LUMISIGHT allergy risk under the microscope in 1,500 patients
Knowledge-focused Not yet recruitingThis study monitors 1,500 adults with breast cancer who receive LUMISIGHT during lumpectomy surgery. Researchers will track how often serious allergic reactions occur within 60 minutes of injection. No new drug is being tested; the goal is to better understand the safety of this …
Sponsor: Lumicell, Inc. • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:30 UTC
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Rare Allergy's hidden toll: study aims to quantify suffering
Knowledge-focused Not yet recruitingHuman seminal plasma allergy is a rare condition causing pain and inflammation after unprotected sex, but its impact on quality of life is poorly understood. This study will enroll 20 women treated at Angers University Hospital to compare standard quality-of-life questionnaires a…
Sponsor: University Hospital, Angers • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:06 UTC