Hypermobility spectrum disorder
MONDO:1040027An array of connective tissue disorders characterized by joint instability and chronic pain. Fatigue and other systemic symptoms that affect daily function may occur as well. These diseases are scored using the Beighton scoring system and one of more secondary musculoskeletal manifestations including post-traumatic symptoms, pain, altered proprioception, and a variety of other characteristics like pes planus, kyphosis, scoliosis, or joint misalignment.
Also known as: BJHS, benign joint hypermobility syndrome, joint hypermobility syndrome
16 clinical trials for this condition and its sub-types.
Follow this condition — get notified about new trialsBroader categories
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Step-by-Step injections aim to ease chronic pain in Loose-Joint conditions
Disease control Not yet recruitingThis study tests a stepwise injection plan for adults with joint hypermobility and instability who haven't improved enough with physical therapy. The first step uses dextrose prolotherapy to stimulate healing in ligaments. If that doesn't reduce pain by at least 40%, participants…
Phase: PHASE1, PHASE2 • Sponsor: Manhattan Pain Medicine, PLLC • Aim: Disease control
Last updated Jul 12, 2026 00:00 UTC
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Simple leg exercises may tighten loose knees in Ehlers-Danlos syndrome
Symptom relief Not yet recruitingThis study tests whether a 12-week program of hamstring strengthening exercises can reduce knee looseness and pain in people with hypermobile Ehlers-Danlos syndrome (hEDS) or hypermobility spectrum disorders (HSD). Twenty participants will attend two supervised exercise classes p…
Phase: NA • Sponsor: University of Calgary • Aim: Symptom relief
Last updated Jun 27, 2026 13:03 UTC
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Long-Term study aims to unlock mystery of joint hypermobility and chronic illness
Knowledge-focused Not yet recruitingThis study will follow 100 health science students for at least 10 years to understand why some people with very flexible joints (hypermobility) develop chronic pain, fatigue, and other health issues while others do not. Researchers will measure balance, heart rate, and quality o…
Sponsor: Clarkson University • Aim: Knowledge-focused
Last updated Jun 27, 2026 14:01 UTC