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Hyperemesis gravidarum

MONDO:0006791

Severe, intractable vomiting during pregnancy (usually the first trimester) accompanied by dehydration, weight loss, and electrolyte imbalances.

Also known as: hyperemesis gravidarum, hyperemesis gravidarum (disease), pernicious vomiting of pregnancy, pregnancy pernicious vomiting

9 clinical trials for this condition and its sub-types.

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Broader categories

Disease (618) Pregnancy disorder (265) Obstetric disorder (20) Human disease (14) Disease by developmental or physiological process (0)

Trials to join now! 3 Not yet recruiting 1 Not yet finished but already full! 2 Completed 3

Metformin may stop severe pregnancy sickness before it starts

Prevention Not yet recruiting

This study tests whether taking metformin-XR (a diabetes drug) daily before pregnancy can lower the risk and severity of Hyperemesis Gravidarum (HG)—extreme nausea and vomiting in pregnancy—in women aged 18-49 who had HG before and are trying to conceive. Participants either take…

Phase: PHASE2 • Sponsor: University of Southern California • Aim: Prevention

Last updated Jun 27, 2026 08:03 UTC