Hyperbilirubinemia

This study tests whether giving oral zinc sulfate and ursodeoxycholic acid alongside standard light therapy can help clear jaundice faster in newborns. About 80 babies with non-hemolytic jaundice will receive one of two doses of zinc, or the liver drug UDCA, plus phototherapy. Th…

This early-stage trial tests a new method to diagnose and treat severe jaundice in newborns. The method uses a non-invasive breath test (ETCOc) to detect hemolysis, a common cause of jaundice. Researchers will compare this approach to standard care in 250 newborns to see if it re…

This study tests whether a steroid drug (methylprednisolone) can help people with severe liver injury caused by medications. The trial includes 232 adults with high bilirubin levels. Participants receive either steroids plus standard care or standard care alone, and doctors track…

This study looks at 116 newborns with jaundice to find the best way to use phototherapy (light treatment). It compares different light intensities and whether taking breaks during treatment works as well as continuous light. The goal is to make treatment more effective and allow …

This study is testing a device that measures carbon monoxide in a newborn's breath to help diagnose jaundice. Jaundice is common in newborns and can be serious if not treated. The device is non-invasive and could replace or reduce the need for blood tests. Researchers will measur…

This trial tests whether kangaroo care—holding a diaper-clad baby skin-to-skin on the chest—can reduce pain during a routine heel-prick blood test in newborns receiving phototherapy for jaundice. It compares two approaches: kangaroo care given by the mother versus by a nurse. The…

This study tests whether adding a medicine called ursodeoxycholic acid (UDCA) to standard light therapy helps clear jaundice faster in newborns. About 70 babies born at 34 weeks or later with jaundice will be randomly assigned to receive either light therapy alone or light therap…

This study looks at how common tooth staining is in children who had very high bilirubin levels (jaundice) early in life. Researchers will check 120 children with certain liver conditions to see if their teeth are discolored and whether that affects their daily life. The goal is …