Hydrocephalus

This study tests a new device called the eShunt System for treating normal pressure hydrocephalus, a condition that causes trouble walking, thinking, and bladder control in older adults. The device drains extra fluid from the brain through a small tube. Researchers will compare i…

This study looks at 100 Ugandan infants under 6 months old with hydrocephalus caused by a brain infection. It compares two surgeries: a standard shunt and a newer procedure called ETV/CPC. The goal is to see which treatment leads to better brain growth and thinking skills over tw…

This study tests whether a brain shunt—a device that drains extra fluid—can improve walking and thinking in older adults with idiopathic normal pressure hydrocephalus (iNPH). One hundred participants will either receive an active shunt or a placebo procedure. The main goal is to …

This study tests a surgery called ETV/CPC as an alternative to standard shunts for infants with hydrocephalus in Uganda. Shunts often fail and need lifelong maintenance, but ETV/CPC aims to give babies a shunt-free life. Researchers will follow 400 infants to see how well the sur…

This pilot study tests a new device called the eShunt, which is placed in a blood vessel to drain extra fluid from the brain in people with normal pressure hydrocephalus (NPH). NPH causes trouble walking, thinking, and bladder control. The device aims to be a less invasive altern…

This study tests a new device called the eShunt System for people with communicating hydrocephalus, a condition where excess fluid builds up in the brain. The device is a small, permanent implant placed through a blood vessel to drain the extra fluid, avoiding the need for tradit…

This study follows 160 people who have or will get a CODMAN CERTAS Plus valve, a device implanted in the brain to drain extra fluid. The main goal is to see if the valve is placed correctly and works without problems 30 days after surgery. Participants include children and adults…

This study tests a new wireless sensor placed in the brain during shunt surgery for hydrocephalus. The sensor aims to let patients and caregivers monitor brain pressure from home, reducing the need for hospital scans and easing fear of shunt blockages. It is a first-in-human safe…

This study tests a small, portable MRI machine for scanning the brains of 100 adults with hydrocephalus or other neurological conditions. Participants get both the portable scan and a standard CT or MRI on the same day. The goal is to see if the portable device can reliably detec…

This study tests whether an AI tool can help radiologists read brain CT and MRI scans more accurately and quickly. Researchers will compare how well doctors, AI alone, and doctors using AI together can spot abnormalities, urgent findings, and classify diseases. The goal is to red…

This study tests whether a special MRI technique called MR elastography can accurately measure high pressure inside the skull without needing a lumbar puncture (spinal tap). Researchers will compare the MRI results with standard tests in 200 people with and without high brain pre…

This study tests a modified soft contact lens to measure pressure inside the skulls of babies at risk for hydrocephalus (fluid buildup in the brain). About 25 infants will wear the lens during standard checkups and before/after surgery. The goal is to see if the lens can accurate…

This study follows 450 older adults to understand why many develop a slow, unsteady walk. Researchers think it may be linked to a treatable brain condition called Normal Pressure Hydrocephalus. They will use brain scans and track health outcomes over six years to find better ways…

This study is observing 328 adults who receive a Neuro-Patch during brain or spine surgery to repair the protective lining around the brain or spinal cord. Researchers are tracking complications and how easy the patch is for surgeons to use. The goal is to gather real-world data …

This study gathers MRI, CT, and ultrasound images from 300 adults—some healthy, some with kidney or brain disease—to build a collection for future not-for-profit research. No new treatments are being tested; the goal is to make medical images available to scientists for advancing…