HHV-6 encephalitis
MONDO:0027029HHV-6 encephalitis refers to inflammation of the brain due to an infection with human herpesvirus 6. People who have undergone allogeneic hematopoietic cell transplantation are at an increased risk for developing HHV-6 encephalitis, particularly when umbilical cord blood stem cells are used. People with immune system disorders may also be at an increased risk for developing this infection. Signs and symptoms vary, but often include confusion, anterograde amnesia (difficulty learning new information following the onset of amnesia), short-term memory loss, and seizures.Diagnosis often involves lumbar puncture, virus testing, and MRI. EEG 's may also be recommendedwhen seizures are suspected. HHV-6 encephalitis is treated with an antiviral agent with activity against HHV-6. Long term outlook (chance of full recovery) can vary considerably depending individual patient factors.
Also known as: Human Herpesvirus 6 encephalitis, Variant A or HHV-6A, Variant B or HHV-6B
52 clinical trials for this condition and its sub-types.
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Which antibiotic combo is safer for your kidneys? new trial aims to find out
Disease control Not yet recruitingThis study compares two common antibiotic combinations—vancomycin with piperacillin/tazobactam versus vancomycin with meropenem—to see which is less harmful to the kidneys. About 852 hospitalized adults with serious infections will be randomly assigned to one of the two combos. T…
Phase: PHASE4 • Sponsor: Bassett Healthcare • Aim: Disease control
Last updated Jun 27, 2026 12:24 UTC
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Rapid brain infection test could slash unnecessary antibiotic use
Diagnosis Not yet recruitingThis study looks at whether a quick diagnostic test (BioFire FilmArray) can accurately predict the cause of meningitis or encephalitis in 182 adults. Participants with symptoms like fever, headache, or confusion will have their spinal fluid tested. The goal is to see if the test …
Phase: NA • Sponsor: Federal University of Health Science of Porto Alegre • Aim: Diagnosis
Last updated Jun 27, 2026 09:08 UTC
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Worldwide ICU infection snapshot aims to save lives
Knowledge-focused Not yet recruitingThis observational study will look at 10,000 adults in intensive care units (ICUs) around the world during a single 24-hour period. Researchers want to find out how common infections and antibiotic-resistant bacteria are, how they are treated, and how patients recover. No new tre…
Sponsor: Universidad de la Sabana • Aim: Knowledge-focused
Last updated Jul 01, 2026 00:00 UTC
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23,000 seniors join study to unlock secrets of aging and infection
Knowledge-focused Not yet recruitingThis research project aims to understand why older adults get more infections and why those infections can be more serious. By following 23,000 people aged 60 and older, scientists will collect health data and samples like blood and stool to study how the immune system changes wi…
Sponsor: Huashan Hospital • Aim: Knowledge-focused
Last updated Jun 27, 2026 13:07 UTC
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30,000 blood samples could revolutionize rapid disease testing
Knowledge-focused Not yet recruitingThis study will collect blood samples from 30,000 adults in the UK with various health conditions, including blood clots, infections, heart disease, diabetes, and more. The samples will be used to develop and fine-tune new diagnostic tests for the cobas® lumira device, which allo…
Sponsor: LumiraDx UK Limited • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:00 UTC
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Can the Body's own 'Off Switch' for inflammation predict who survives severe infection?
Knowledge-focused Not yet recruitingThis study will follow 300 adults with severe infections in the ICU to see how levels of specialized pro-resolving mediators (SPMs)—natural molecules that help stop inflammation—change over time. Researchers will use blood samples already collected during routine care, so no extr…
Sponsor: Second Affiliated Hospital of Wenzhou Medical University • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:12 UTC