Herpes simplex type 1 infectious disease

This early-stage trial tested whether a new herpes vaccine called HSV529 is safe for people. Researchers gave the vaccine or a placebo to 69 healthy adults aged 18 to 40, some of whom had herpes and some who did not. Participants received three shots over six months and were moni…

This study tested whether the antiviral drug valacyclovir (Valtrex) could slow brain changes linked to Alzheimer's in 50 people with mild cognitive impairment who also had herpes simplex virus antibodies. Participants took either valacyclovir or a placebo for 52 weeks. The goal w…

This study tested whether the antiviral drug valacyclovir (Valtrex) can slow memory loss in people with mild Alzheimer's disease who also carry the herpes simplex virus. About 120 participants received either the drug or a placebo for 18 months. The goal was to see if treating th…