Hereditary gingival fibromatosis
MONDO:0016070Hereditary gingival fibromatosis (HGF) is a rare benign, slowly progressive, non-inflammatory fibrous hyperplasia of the maxillary and mandibular gingivae that generally occurs with the eruption of the permanent (or more rarely the primary) dentition or even at birth. It presents as a localized or generalized, smooth or nodular overgrowth of the gingival tissues of varying severity. It can be isolated, with autosomal dominant inheritance, or as part of a syndrome.
Also known as: autosomal dominant gingival fibromatosis, autosomal dominant gingival hyperplasia, hereditary gingival fibromatosis, hereditary gingival hyperplasia
53 clinical trials for this condition and its sub-types.
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Broader categories
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Custom 3D-Printed bone grafts could improve dental implant success
Disease control Not yet recruitingThis study looks at how well 3D printed bone grafts work for supporting dental implants in people with gum disease or bone loss. Researchers will check if the implants stay stable and how much the graft shrinks over 1 to 6 years. About 100 healthy adults who already received this…
Sponsor: University of Guarulhos • Aim: Disease control
Last updated Jun 27, 2026 12:24 UTC
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Gum disease in 95% of pregnant women: can simple brushing lessons help?
Disease control Not yet recruitingThis study tests a new program that teaches pregnant women in Bangladesh how to care for their teeth and gums during routine prenatal visits. Over 95% of pregnant women in Bangladesh have gum disease, but oral health is not part of standard pregnancy care. The study will compare …
Phase: NA • Sponsor: Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh • Aim: Disease control
Last updated Jun 27, 2026 12:03 UTC
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Mail-In breath test could end bad breath diagnosis travel
Diagnosis Not yet recruitingThis study tests whether breath samples collected in special bags remain stable for up to 7 days, which could allow people with bad breath (halitosis) to provide samples from home instead of traveling to a clinic. Researchers will compare gas levels measured right away and after …
Phase: NA • Sponsor: University Hospital, Strasbourg, France • Aim: Diagnosis
Last updated Jun 27, 2026 13:00 UTC
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Gum disease detection: could a questionnaire replace the Dentist's probe?
Diagnosis Not yet recruitingThis study will check if a simple questionnaire can accurately identify gum disease in adults. About 291 participants in Saudi Arabia will fill out the questionnaire and then have a standard dental exam. The goal is to see how well the questionnaire matches the exam results, whic…
Sponsor: Universiti Sains Malaysia • Aim: Diagnosis
Last updated Jun 27, 2026 09:05 UTC
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AI-Powered selfies could spot gum disease without a dentist visit
Diagnosis Not yet recruitingThis study will enroll 2,000 adults to see if non-invasive methods like smartphone photos, dental X-rays, and questionnaires can accurately detect gum disease compared to a standard clinical exam. Researchers will use artificial intelligence to analyze the images and combine data…
Sponsor: Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University • Aim: Diagnosis
Last updated Jun 26, 2026 16:01 UTC
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New pill aims to shield stomachs from common painkiller damage
Prevention Not yet recruitingThis study tests whether a new medicine called Fexuprazan (Fexuclue) can prevent stomach ulcers caused by NSAID painkillers like ibuprofen. About 360 adults with joint or muscle pain who need daily NSAIDs will take either Fexuprazan or an older drug (Lansoprazole) for 24 weeks. T…
Phase: PHASE4 • Sponsor: Daewoong Pharmaceutical Co. LTD. • Aim: Prevention
Last updated Jun 27, 2026 12:07 UTC
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Can your own blood and fat heal aching joints? new trial aims to find out
Symptom relief Not yet recruitingThis early-phase trial will test four orthobiologic treatments—PRP, bone marrow concentrate, hyaluronic acid, and nanofat—in 300 adults with various muscle, joint, tendon, or bone conditions. The goal is to see if these natural substances can reduce pain and improve joint functio…
Phase: EARLY_PHASE1 • Sponsor: PROREGEN • Aim: Symptom relief
Last updated Jun 27, 2026 09:08 UTC
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Phone app may boost exercise for aching joints
Symptom relief Not yet recruitingThis study looks at whether a mobile app can help people with common pains (neck, shoulder, back, or knee) do their prescribed home exercises more regularly. About 30 adults will be split into two groups: one using the app and one doing traditional exercises. The goal is to see i…
Phase: NA • Sponsor: National Yang Ming Chiao Tung University • Aim: Symptom relief
Last updated Jun 27, 2026 08:12 UTC
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New urdu tool could help millions with muscle and joint pain
Knowledge-focused Not yet recruitingThis study aims to translate and adapt a widely used questionnaire for musculoskeletal problems into Urdu. Researchers will enroll 110 Urdu-speaking adults, including patients with muscle or joint issues and healthy volunteers. The goal is to create a validated tool to measure sy…
Sponsor: Riphah International University • Aim: Knowledge-focused
Last updated Jun 27, 2026 13:02 UTC
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AI vs. doctor: which note do patients trust more?
Knowledge-focused Not yet recruitingThis study looks at how patients feel when reading their own medical notes. Some will read the original doctor's note, others will read a simpler version written by artificial intelligence. Researchers want to see if the AI summary changes how much patients trust their doctor or …
Phase: NA • Sponsor: University of Texas at Austin • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:36 UTC
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Dental AI learns from 150 patients in new data study
Knowledge-focused Not yet recruitingThis study gathers mouth pictures from 150 adults with different gum conditions to teach an AI system how to spot gum disease. Participants simply have their teeth and gums photographed with a special probe. No treatment or medication is involved—just data collection to improve f…
Phase: NA • Sponsor: LuminX • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:29 UTC
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Gum disease smarts: do dental students know more than psychology students?
Knowledge-focused Not yet recruitingThis study looks at how much final-year dentistry and psychology students know about gum disease (periodontitis) and whether that knowledge is linked to their own gum health. About 60 students will fill out a questionnaire and get a dental check-up. The goal is to see if more kno…
Sponsor: Universitat Internacional de Catalunya • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:06 UTC
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New digital tool aims to speed up return to work for those with muscle pain
Knowledge-focused Not yet recruitingThis study tests a decision support system called SmaRTWork to help people on sick leave due to muscle or back pain return to work. About 298 adults in Norway will either use the system or receive usual care. The main goal is to see if the tool helps them return to work sustainab…
Phase: NA • Sponsor: Norwegian University of Science and Technology • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:11 UTC