Headache disorder
MONDO:0021146Various conditions with the symptom of headache. Headache disorders are classified into major groups, such as primary headache disorders (based on characteristics of their headache symptoms) and secondary headache disorders (based on their etiologies). (International Classification of Headache Disorders, 2nd ed. Cephalalgia 2004: suppl 1)
Also known as: headache disorder, cephalgia syndrome, cephalgia syndromes, chronic daily headache, chronic daily headaches, chronic headache, chronic headaches, daily headache, chronic
491 clinical trials for this condition and its sub-types, 119 tagged with Headache disorder itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
Browse by category →Sub-types of Headache disorder
-
Hypnic headache 8 trials · 431 incl. sub-types
2 sub-types
- Migraine disorder 393 trials · 414 incl. sub-types Sub-types →
- Trigeminal autonomic cephalalgia 8 trials · 27 incl. sub-types Sub-types →
-
Spontaneous intracranial hypotension 7 trials
-
Exertional headache 0 trials
Most studied deeper sub-types
-
Migraine prevention drug trial in kids halted early
Prevention Stopped earlyThis study tested a drug called SPN-538 to prevent migraines in children aged 6 to 11. The trial was a randomized, double-blind, placebo-controlled study, meaning some children got the drug and some got a placebo. However, the study was terminated early and only enrolled 26 parti…
Phase 4 • Sponsor: Supernus Pharmaceuticals, Inc. • Aim: Prevention
Last updated Jun 27, 2026 08:12 UTC
-
Nerve block or antidepressant? study tests two migraine treatments Head-to-Head
Symptom relief Stopped earlyThis study compares two treatments for transformed migraine (chronic daily headache): a sphenopalatine ganglion nerve block using lidocaine gel applied inside the nose, versus daily oral amitriptyline (Elavil), an antidepressant often used for migraine prevention. Ten adults aged…
Phase 4 • Sponsor: Rutgers, The State University of New Jersey • Aim: Symptom relief
Last updated Jun 27, 2026 14:03 UTC
-
Migraine ER drug trial halted early – no clear results
Symptom relief Stopped earlyThis study tested whether adding clorazepate (a sedative) to standard migraine medications could provide faster pain relief for people having a migraine attack in the emergency room. The trial included 323 adults with moderate to severe migraine. However, the study was terminated…
Phase 3 • Sponsor: Assistance Publique - Hôpitaux de Paris • Aim: Symptom relief
Last updated Jun 26, 2026 14:44 UTC
-
Nurse phone calls may boost headache treatment success
Knowledge-focused Stopped earlyThis study looked at whether follow-up calls from a headache nurse could help patients with migraines, tension headaches, cluster headaches, or hemicrania continua stay on their preventive medication. 147 participants were randomly assigned to receive nurse calls at 2 and 6 weeks…
Sponsor: Norwegian University of Science and Technology • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:07 UTC