Hb Bart's hydrops fetalis
MONDO:0015579Alpha thalassemia caused by variation in all four copies of the alpha hemoglobin genes (e.g., homozygous deletion encompassing HBA1 and HBA2).
Also known as: Alpha-thalassemia major, HBA1;HBA2 digenic quadallelic Hb Bart’s hydrops fetalis, Haemoglobin Bart's hydrops fetalis, Hb Bart’s hydrops fetalis caused by quadallelic variation in HBA1;HBA2, Hb Bart’s hydrops fetalis related to quadallelic variation in HBA1 and HBA2, Hemoglobin Bart's hydrops fetalis, alpha-thalassemia hydrops fetalis, homozygous alpha0-thalassemia
16 clinical trials for this condition and its sub-types.
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New pill may cut transfusions for thalassemia patients
Disease control OngoingThis phase 3 study tests whether mitapivat, an oral medication, can safely reduce the number of blood transfusions needed by adults with transfusion-dependent alpha- or beta-thalassemia. Participants receive either mitapivat or a placebo for 48 weeks. The main goal is to see if m…
Phase: PHASE3 • Sponsor: Agios Pharmaceuticals, Inc. • Aim: Disease control
Last updated Aug 02, 2026 00:00 UTC
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Could a simple exercise routine strengthen bones in thalassemia?
Disease control OngoingThis trial investigates whether a 12- to 36-week program of aerobic and strength exercises can improve body composition, muscle function, and bone density in adolescents and adults with thalassemia. Participants will follow a self-directed routine of 30 minutes of exercise, 5 day…
Phase: NA • Sponsor: University of California, San Francisco • Aim: Disease control
Last updated Jul 24, 2026 00:00 UTC
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New cord blood matching method could expand transplant access for blood cancer patients
Disease control OngoingThis study tests a new approach to stem cell transplants for people with blood cancers like leukemia and lymphoma. Patients receive a combination of umbilical cord blood and stem cells from a family member, with the cord blood chosen based on specific genetic markers rather than …
Phase: PHASE2 • Sponsor: Weill Medical College of Cornell University • Aim: Disease control
Last updated Jun 26, 2026 13:02 UTC