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Hand-foot syndrome

MONDO:0700048

A condition characterized by redness, pain, swelling, and tingling in the palms of the hands or the soles of the feet. It may appear as a side effect to chemotherapy agents.

Also known as: palmar-plantar erythrodysthesia

9 clinical trials for this condition and its sub-types.

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Broader categories

Disease (680) Skin disorder (132) Syndromic disease (25) Human disease (14) Disease by body system or component (0) Integumentary system disorder (0)

Trials to join now! 1 Not yet recruiting 3 Not yet finished but already full! 1 Completed 4

Simple gel may prevent painful side effect of liver cancer drug

Symptom relief Recruiting now

This study tests if applying a topical gel (indomethacin) to the hands before starting sorafenib can prevent or reduce hand-foot skin reactions, a common and painful side effect. About 39 adults with advanced liver cancer will use the gel twice daily for up to 12 weeks. The goal …

Phase: PHASE2 • Sponsor: National Taiwan University Hospital • Aim: Symptom relief

Last updated Jun 27, 2026 12:28 UTC