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Hand-foot syndrome

MONDO:0700048

A condition characterized by redness, pain, swelling, and tingling in the palms of the hands or the soles of the feet. It may appear as a side effect to chemotherapy agents.

Also known as: palmar-plantar erythrodysthesia

9 clinical trials for this condition and its sub-types.

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Broader categories

Disease (680) Skin disorder (132) Syndromic disease (25) Human disease (14) Disease by body system or component (0) Integumentary system disorder (0)

Trials to join now! 1 Not yet recruiting 3 Not yet finished but already full! 1 Completed 4

Vitamin B12 shows promise in preventing chemo side effect

Prevention Ongoing

This phase 3 trial tests whether mecobalamin (a form of vitamin B12) can prevent severe hand-foot syndrome in early breast cancer patients taking capecitabine. About 234 women will receive either mecobalamin or a placebo. The goal is to see if the vitamin reduces painful skin rea…

Phase: PHASE3 • Sponsor: Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University • Aim: Prevention

Last updated Jun 27, 2026 09:01 UTC