Graves disease
MONDO:0005364Graves' disease is an autoimmune disorder that leads to overactivity of the thyroid gland (hyperthyroidism).It is caused by an abnormal immune system response that causes the thyroid gland to produce too much thyroid hormones. Graves disease is the most common cause of hyperthyroidism andoccurs mostoften in women over age 20. However, the disorder may occur at any age and may affect males as well.Treatmentmayinclude radioiodine therapy, antithyroid drugs, and/or thyroid surgery.
Also known as: Graves disease, Basedow disease, Graves' hyperthyroidism, parry disease
88 clinical trials for this condition and its sub-types, 53 tagged with Graves disease itself.
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Sub-types of Graves disease
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Pediatric-onset Graves disease 0 trials
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New drug aims to tame Graves' disease Long-Term
Disease control By invitation onlyThis study tests a drug called IMVT-1402 in adults with Graves' disease, a condition where the immune system attacks the thyroid. The goal is to see if the drug can help patients stay healthy without needing other treatments. About 372 people who completed earlier studies will ta…
Phase 2 • Sponsor: Immunovant Sciences GmbH • Aim: Disease control
Last updated Jul 29, 2026 00:00 UTC
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New injection every 8 weeks shows promise for thyroid eye disease
Disease control OngoingThis study tests a drug called TOUR006 in 79 people with active thyroid eye disease, a condition that causes eye bulging and inflammation. Participants receive either a low dose, high dose, or placebo injection every 8 weeks. The main goal is to see if the drug can reduce eye bul…
Phase 2 • Sponsor: Tourmaline Bio, Inc., a Novartis Company • Aim: Disease control
Last updated Jun 27, 2026 12:23 UTC
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Dietary intervention aims to tame weight regain in Graves' patients
Disease control OngoingThis study tests whether a personalized low-calorie Mediterranean-style diet, combined with lifestyle coaching, can prevent people newly diagnosed with Graves' disease from regaining too much weight after their thyroid levels normalize. Fifty-four adults will be randomly assigned…
Sponsor: Istituti Clinici Scientifici Maugeri SpA • Aim: Disease control
Last updated Jun 27, 2026 12:05 UTC
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New study sheds light on thyroid disease in kids under 6
Knowledge-focused By invitation onlyThis study examines autoimmune hyperthyroidism in children diagnosed before age 6, focusing on their symptoms, growth, and response to treatment. Researchers will compare these young children with older children who have the same condition. The goal is to identify patterns that c…
Sponsor: IRCCS Ospedale San Raffaele • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:23 UTC
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Vaccine link to thyroid disease under investigation
Knowledge-focused OngoingThis study looks at whether COVID-19 vaccination might trigger Graves' disease, a condition where the immune system attacks the thyroid. Researchers will review medical records of 161 people who developed Graves' disease for the first time between March 2020 and October 2022. The…
Sponsor: Laura ICONARU • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:54 UTC
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Thyroid Surgery's heart impact study pulled before start
Knowledge-focused CancelledThis study aimed to see if thyroid surgery changes the thickness of the carotid artery, which is a sign of heart disease risk. It planned to measure artery thickness before and after surgery in adults with various thyroid conditions. However, the study was withdrawn before enroll…
Sponsor: Istituto Auxologico Italiano • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:52 UTC