Glucocorticoid-induced osteoporosis
MONDO:0000757An osteoporosis caused by chronic glucocorticoid use. Glucocorticoids impair the replication, differentiation and function of osteoblasts and induce the apoptosis of mature osteoblasts and osteocytes; the also favor osteoclastogenesis leading to an increase in bone resorption.
Also known as: steroid-induced osteoporosis
5 clinical trials for this condition and its sub-types.
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Bone drug showdown: which works better for Steroid-Weakened bones?
Disease control CompletedThis study looked at two osteoporosis medications—romosozumab and denosumab—in 54 people who take long-term steroids and have weak bones. Participants first received either romosozumab for 12 months followed by denosumab, or denosumab alone for 24 months. Then everyone stayed on …
Phase: PHASE4 • Sponsor: Tuen Mun Hospital • Aim: Disease control
Last updated Jun 27, 2026 12:29 UTC
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Best way to switch osteoporosis meds after denosumab? small study tests timing
Disease control CompletedThis study looked at 45 people with osteoporosis caused by long-term steroid use. Participants had stopped taking denosumab and were switched to either zoledronic acid or alendronate at different times. The goal was to see which timing and drug best controlled bone loss markers. …
Phase: PHASE4 • Sponsor: University of Alabama at Birmingham • Aim: Disease control
Last updated Jun 27, 2026 12:23 UTC