Fuchs' endothelial dystrophy
MONDO:0005321Fuchs endothelial corneal dystrophy (FECD) is the most frequent form of posterior corneal dystrophy and is characterized by excrescences on a thickened Descemet membrane (corneal guttae), generalized corneal edema, with gradually decreased visual acuity.
Also known as: Endoepithelial corneal dystrophy, FECD, Fuchs endothelial dystrophy, corneal dystrophy, Fuchs endothelial, late hereditary endothelial dystrophy, Fuchs endothelial corneal dystrophy
40 clinical trials for this condition and its sub-types, 33 tagged with Fuchs' endothelial dystrophy itself.
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Sub-types of Fuchs' endothelial dystrophy
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Can eye drops offer a new way to treat fuchs dystrophy?
Disease control CompletedThis clinical trial is testing whether an investigational eye drop called STN1010904 can improve vision in people with Fuchs endothelial corneal dystrophy (FECD), a condition that damages the cornea's inner layer and can lead to blurry vision. The study will compare two different…
Phase 2 • Sponsor: Santen Inc. • Aim: Disease control
Last updated Aug 09, 2026 00:00 UTC
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New eye drops aim to speed vision recovery after cornea surgery
Disease control CompletedThis study tested whether ripasudil eye drops can help people with Fuchs endothelial corneal dystrophy recover vision faster after a specific cornea procedure called descemetorhexis. The trial involved 107 adults and compared the drops to a placebo over 12 weeks of treatment, fol…
Phase 3 • Sponsor: Kowa Research Institute, Inc. • Aim: Disease control
Last updated Jun 27, 2026 12:37 UTC
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New eye drops aim to speed vision recovery after cornea surgery
Disease control CompletedThis study tested whether ripasudil eye drops can help people with Fuchs endothelial corneal dystrophy recover vision faster after combined cataract and cornea surgery. 110 adults received either the eye drops or a placebo for 12 weeks, followed by a taper and 38-week follow-up. …
Phase 3 • Sponsor: Kowa Research Institute, Inc. • Aim: Disease control
Last updated Jun 27, 2026 08:13 UTC
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Built-In eye scanner could give surgeons a live 3D view during operations
Knowledge-focused CompletedThis study tests a microscope that has an OCT scanner built directly into it, allowing surgeons to take detailed cross-sectional images of the eye during surgery. The goal is to see if this setup is practical and whether the extra visual information helps guide surgical decisions…
Sponsor: The Cleveland Clinic • Aim: Knowledge-focused
Last updated Aug 05, 2026 00:00 UTC
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Eye surgery showdown: which cornea transplant is safer?
Knowledge-focused CompletedThis study compared two types of cornea transplant surgery (DSAEK and DMEK) for people with Fuchs' endothelial dystrophy, a condition that clouds the cornea. Researchers measured vision and tracked side effects like swelling and eye pressure in 112 participants. The goal was to f…
Sponsor: University of Aarhus • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:25 UTC
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Does donor diabetes impact corneal transplant outcomes?
Knowledge-focused CompletedThis completed study looked at whether diabetes in a cornea donor affects the success of a corneal transplant called DMEK. Over 1,000 participants received a cornea from either a donor with or without diabetes. Researchers tracked graft failure and cell loss for one year to see i…
Sponsor: Case Western Reserve University • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:08 UTC