Cure My Disease

Don't miss your cure!

 Log in / Sign up

Frontonasal dysplasia

MONDO:0016643

A group of rare bone development disorders characterized by an array of abnormalities affecting the eyes, forehead, and nose, and linked to midfacial dysraphia. The clinical picture is highly variable, but the major findings include hypertelorism, a broad nasal root, a large and bifid nasal tip, and widow's peak. Occasionally, abnormalities can include accessory nasal tags, cleft lip, ocular abnormalities (coloboma, cataract, microphthalmia), conductive hearing loss, basal encephalocele and/or agenesis of the corpus callosum. Intellectual deficit is rare and more likely to occur in cases where hypertelorism is severe or where there is extra-cranial involvement.

Also known as: median cleft face syndrome, FND1, frontonasal dysplasia 1, median cleft syndrome

36 clinical trials for this condition and its sub-types.

Follow this condition — get notified about new trials

Sub-types

Acromelic frontonasal dysostosis (0) Craniofrontonasal dysplasia-Poland anomaly syndrome (0) Frontofacionasal dysplasia (0) Frontonasal dysplasia - severe microphthalmia - severe facial clefting syndrome (0) Frontonasal dysplasia with alopecia and genital anomaly (0) Frontorhiny (0) Oculoauriculofrontonasal syndrome (0) Pai syndrome (0) Six2-related frontonasal dysplasia (0)

Broader categories

Disease (618) Musculoskeletal system disorder (196) Hereditary disease (172) Bone disorder (47) Human disease (14) Skeletal system disorder (4) Bone development disease (2) Disease of genetic or genomic mechanism (2) Disease by body system or component (0) Disease by developmental or physiological process (0)
Trials to join now! 17 Not yet recruiting 6 Not yet finished but already full! 4 Completed 8 Terminated 1
Sort by