Familial spontaneous pneumothorax
MONDO:0008259Familial spontaneous pneumothorax is a rare, genetic pulmonary disease characterized by the uni- or bilateral accumulation of air in the pleural cavity in persons with a positive family history and no underlying lung disease or previous chest trauma. Patients typically present dyspnea associated with acute onset of sharp and steady pleutiric chest pain of variable severity (which resolves within 24h even though pneumothorax is still present). Reflex tachycardia and/or respiratory or circulatory compromise may be observed. Other syndromes (e.g. Birt-Hogg-Dube, Marfan or Ehlers-Danlos syndromes) may be associated.
Also known as: Psp, pneumothorax, primary spontaneous, primary spontaneous pneumothorax, spontaneous pneumothorax
21 clinical trials for this condition and its sub-types.
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Could skipping the chest tube be just as safe for a collapsed lung?
Disease control Not yet recruitingThis study compares two approaches for treating a large primary spontaneous pneumothorax (collapsed lung) in stable adults: active observation (monitoring without an invasive procedure) versus standard chest tube drainage. About 436 participants will be randomly assigned to one o…
Phase: NA • Sponsor: Corporacion Parc Tauli • Aim: Disease control
Last updated Jun 27, 2026 08:10 UTC
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Numbing injection may ease pain after incontinence surgery
Symptom relief Not yet recruitingThis study tests whether injecting a numbing medicine (bupivacaine) into the surgical site during sling surgery for stress urinary incontinence can reduce pelvic and thigh pain after the operation. Sixty women will be randomly assigned to receive either the numbing medicine or a …
Phase: NA • Sponsor: Hadassah Medical Organization • Aim: Symptom relief
Last updated Jun 27, 2026 14:03 UTC
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New nerve block technique could reduce opioid use in lung exams
Symptom relief Not yet recruitingThis study tests whether an ultrasound-guided nerve block (erector spinae plane block) provides better pain relief than standard local anesthesia during a lung procedure called medical thoracoscopy. One hundred adults scheduled for this procedure will be randomly assigned to rece…
Phase: PHASE2, PHASE3 • Sponsor: Kafrelsheikh University • Aim: Symptom relief
Last updated Jun 27, 2026 12:31 UTC
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Cartoons and stories soothe Kids' fear during breathing treatments
Symptom relief Not yet recruitingThis study looks at whether watching cartoons or listening to breath-synchronized interactive stories can help children aged 6-9 feel less afraid and more comfortable while using a nebulizer for breathing medication. About 96 children with respiratory conditions will be randomly …
Phase: NA • Sponsor: Mersin University • Aim: Symptom relief
Last updated Jun 27, 2026 12:04 UTC
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Cold therapy could take the ouch out of blood tests
Symptom relief Not yet recruitingThis study tests if applying cold (cryotherapy) to the wrist before a blood draw from the artery can reduce pain. It involves 258 adults with chronic respiratory diseases who need this test. The goal is to find a simple, drug-free way to make the procedure less painful.
Phase: PHASE3 • Sponsor: University Hospital, Brest • Aim: Symptom relief
Last updated Jun 27, 2026 09:04 UTC
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Which talc method works best for a leaky lung?
Symptom relief Not yet recruitingThis study looks at two methods of giving talc to treat fluid buildup or collapsed lung. About 160 people aged 12 and older will get either talc mixed with liquid or talc sprayed as a powder. The goal is to see which method works better, causes fewer side effects, and leads to a …
Phase: NA • Sponsor: University of Health Sciences Lahore • Aim: Symptom relief
Last updated Jun 27, 2026 08:08 UTC
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Home treatment for collapsed lung could spare patients a hospital stay
Symptom relief Not yet recruitingThis study compares outpatient (home) care to standard hospital care for people having their first large collapsed lung. 386 adults aged 18-50 will be randomly assigned to either go home with a small chest tube and valve or stay in the hospital. The goal is to see if home treatme…
Phase: NA • Sponsor: University Hospital, Strasbourg, France • Aim: Symptom relief
Last updated Jun 27, 2026 08:00 UTC
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Smart sensors could track brain disease at home
Knowledge-focused Not yet recruitingThis study will test whether wearable sensors can accurately monitor movement problems in people with progressive supranuclear palsy (PSP) and dementia with Lewy bodies (DLB). About 60 participants will wear small sensors on their chest, ankles, and wrists while doing simple task…
Sponsor: BioSensics • Aim: Knowledge-focused
Last updated Jul 03, 2026 00:00 UTC