Familial clubfoot with or without associated lower limb anomalies
MONDO:0016046Familial clubfoot with or without associated lower limb anomalies is a rare congenital limb malformation syndrome characterized by malalignment of the bones and joints of the foot and ankle, with presence of forefoot and midfoot adductus, hindfoot varus, and ankle equinus, presenting as rigid inward turning of the foot towards the midline, in various members of a single family. Hypoplasia of lower leg muscles is a frequently associated finding. Patients may present with other low-limb malformations, such as patellar hypoplasia, oblique talus, tibial hemimelia, and polydactyly.
23 clinical trials for this condition and its sub-types.
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Broader categories
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Small plate, big hope: new surgery may fix clubfoot without cutting bone
Disease control CompletedThis study tested a new, less invasive surgery for children aged 4 to 10 with a stubborn clubfoot deformity called 'bean-shaped foot.' Instead of cutting bones, surgeons placed a small metal plate across a joint in the foot to gently guide growth and straighten the foot over time…
Sponsor: Cairo University • Aim: Disease control
Last updated Jun 27, 2026 13:00 UTC
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New stretching routine may stop clubfoot relapse in kids
Disease control CompletedThis study looked at 32 children with clubfoot who were already treated with the Ponseti method. Researchers wanted to see if adding myofascial release and static stretching to nighttime bracing could prevent the foot from relapsing. The children received therapy sessions and wer…
Phase: NA • Sponsor: Riphah International University • Aim: Disease control
Last updated Jun 27, 2026 12:03 UTC
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Needle-Free jet injection matches cream for pain relief in clubfoot babies
Symptom relief CompletedThis study tested two numbing methods for a common clubfoot procedure in infants: a needle-free jet injection that works in 1-2 minutes versus a topical cream that takes 30 minutes. Researchers measured pain using a standard scale, heart rate, and oxygen levels in 107 babies. The…
Phase: PHASE4 • Sponsor: Vanderbilt University Medical Center • Aim: Symptom relief
Last updated Jun 27, 2026 12:29 UTC
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Kids test new bionic foot design
Knowledge-focused CompletedThis study tested a new prosthetic foot for children with leg amputations or birth defects. Thirteen kids walked with the device and gave feedback on stiffness and performance. The goal was to gather ideas to improve future foot designs.
Sponsor: Össur Iceland ehf • Aim: Knowledge-focused
Last updated Jun 27, 2026 14:00 UTC
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Gene sequencing uncovers mysterious fetal malformations
Knowledge-focused CompletedThis study tested whether a powerful DNA test called high-throughput exome sequencing can find genetic causes of multiple birth defects in fetuses when standard exams fail. Researchers studied 100 fetuses with at least two malformations and no prior diagnosis. They compared the n…
Sponsor: Centre Hospitalier Universitaire Dijon • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:03 UTC
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Speedy gene test aims to give answers on birth defects in just 7 days
Knowledge-focused CompletedThis study tested whether a fast type of genetic test called rapid genome sequencing can find the cause of birth defects seen on ultrasound more quickly than current methods. Researchers included 184 pregnancies with certain ultrasound findings. The goal was to see if results cou…
Sponsor: Centre Hospitalier Universitaire Dijon • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:00 UTC
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Can flat feet or knock knees affect how kids move? new study investigates
Knowledge-focused CompletedThis completed study looked at 151 children with common postural conditions like flat feet, knock knees, or scoliosis. Researchers used wearable motion sensors and clinical tests to measure balance and motor control, then compared the results to healthy children. The goal was to …
Phase: NA • Sponsor: Istituto Ortopedico Rizzoli • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:06 UTC
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Video footage may help doctors decide clubfoot treatment
Knowledge-focused CompletedThis completed study involved 55 children with clubfoot who could walk. Researchers showed videos of the children's feet to experienced surgeons and asked for treatment recommendations. The goal was to see if a video-based scoring system (PBS-score) matches what surgeons would re…
Sponsor: Region Stockholm • Aim: Knowledge-focused
Last updated Jun 26, 2026 17:08 UTC
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Video checkups for clubfoot: reliable or not?
Knowledge-focused CompletedThis study looked at whether doctors can reliably score clubfoot severity from video recordings instead of in-person exams. 55 children with clubfoot were assessed by multiple raters using a standard scoring tool. The goal was to see if video assessments could be a trustworthy op…
Sponsor: Region Stockholm • Aim: Knowledge-focused
Last updated Jun 26, 2026 17:03 UTC