Familial clubfoot with or without associated lower limb anomalies

This study compares two common surgeries for correcting clubfoot in children aged 2-5 who have not been treated before. The goal is to see which method better improves ankle movement and has fewer complications like bleeding or infection. About 44 children will take part, and res…

This trial compares two surgical tools—a standard surgical blade and a special ophthalmic knife—for cutting the Achilles tendon in children aged 2 to 5 with clubfoot. The goal is to see which tool improves ankle movement more and causes fewer problems like bleeding or infection. …

Club foot is a common birth defect where a baby's foot is twisted out of shape. The standard treatment uses weekly plaster casts to gradually correct the foot. This study tests whether changing the cast twice a week instead of once works just as well or better. About 144 babies u…

This trial tests a wearable robot called ENMS-BSF that combines soft muscles, electrical stimulation, and balance feedback to correct foot drop and foot inversion after a stroke. Sixty people who had a stroke at least six months ago and have mild-to-moderate walking problems will…

This study looks at whether adding a foot abduction brace to the French method (a stretching and taping technique) helps babies with clubfoot more than the French method alone. Researchers will enroll 18 infants under 12 months old who have not had prior treatment. They will meas…

This study tests if a less invasive freezing technique (cryoneurotomy) works as well as surgery to reduce foot stiffness in people who had a stroke. About 114 adults with chronic foot spasticity will be randomly assigned to one of the two treatments. The goal is to see if the fre…

This study tests whether applying Mastisol, a liquid adhesive, during clubfoot casting helps babies with clubfeet get better faster and with fewer problems. Researchers will compare outcomes like how many weeks of casting are needed and how often complications like sores or swell…

This pilot study looks at how botulinum toxin (Botox) injections affect the muscles, tendons, and nerves in the feet of people who have had a stroke and developed a tight, twisted foot (equinovarus). Researchers will use special ultrasound and movement tests to track these change…

This study looks at DNA methylation patterns (chemical tags on DNA) in fetuses with rare genetic diseases. Researchers will analyze DNA from amniotic fluid and tissue samples to create reference signatures. The goal is to improve diagnosis of these conditions before birth. The st…

This study is testing whether using rapid genetic sequencing can help doctors diagnose and treat birth defects in newborns in intensive care. Researchers will enroll 2,000 babies and compare death rates, disability rates, and genetic findings. The goal is to see if personalized t…