Eye degenerative disorder

This study tests whether using cord blood, rich in fetal hemoglobin, for transfusions in preterm infants can reduce serious complications like blindness, lung disease, and gut problems. Researchers will compare outcomes in 200 very low birth weight babies who receive either cord …

This study compares transfusions using red blood cells from umbilical cord blood versus standard adult donor blood in extremely premature infants. About 176 babies born before 28 weeks or weighing under 1000 grams will be enrolled. The goal is to see if cord blood reduces the ris…

This study will enroll about 3,890 children aged 8-12 who still have rapidly worsening nearsightedness (myopia) even after using orthokeratology (Ortho-K) lenses. Researchers will compare four approaches: continuing Ortho-K alone, adding low-dose atropine eye drops, using lenses …

This study tests special glasses called D.D.C dual-control lenses to see if they can slow down worsening nearsightedness (myopia) in children aged 6 to 14. Over 24 months, 316 kids will wear either the new lenses or standard glasses. The goal is to measure changes in eye prescrip…

This study tests if low-intensity red light therapy can slow or stop the worsening of high and extreme myopia (severe nearsightedness) in adults aged 18 to 45. The treatment has shown promise in children, but its effects in adults are unknown. The goal is to prevent vision loss a…

This study tests if using a special LED red light device twice a day, along with glasses that have defocus lenses, can slow the progression of nearsightedness (myopia) in children aged 6 to 14. About 364 kids will be randomly assigned to different groups to find the best treatmen…

This trial tests whether an enhanced monofocal intraocular lens, set for monovision (one eye for distance, one for near), improves vision without glasses in people with both cataracts and high myopia. Sixty-six participants will receive the lens in both eyes and be followed for o…

This study will test a new artificial intelligence (AI) system that reads eye scans (OCT) to diagnose common blinding eye diseases like diabetic retinopathy, glaucoma, and age-related macular degeneration. Researchers will collect 2000 eye scans from patients at Peking Union Medi…

This trial tests whether a fentanyl nasal spray can reduce pain during eye exams for retinopathy of prematurity (ROP) in preterm infants. About 58 babies born at or before 31 weeks will receive either fentanyl or a saltwater placebo before their routine exam, along with standard …

This trial aims to see if educational videos or audio messages can improve parents' knowledge and practices about retinopathy of prematurity (ROP) screening. About 99 parents of premature infants in Karachi will receive either a video, audio, or standard pamphlet. Their understan…

This study looks at whether giving eye doctors AI-generated measurements from retinal images helps them write more accurate and complete reports. About 29 ophthalmologists and trainees will be randomly assigned to use AI tools or just the original images. A panel of senior expert…

This study looks at children born prematurely who had retinopathy of prematurity (ROP), a disease that can cause blindness. Some were treated with laser, others with injections, and some had ROP but no treatment. Researchers will compare their vision and retina structure to see w…