Extrapyramidal and movement disease

This study tests deep brain stimulation (DBS) surgery for people with severe focal hand dystonia, including musician's dystonia, that hasn't improved with botulinum toxin. Five participants will have electrodes placed in brain areas that control movement, connected to a stimulato…

This study offers voluntary screening for newborns in North Carolina to detect a wide range of rare health conditions early. Using a small blood sample already collected at birth, the program tests for dozens of disorders, including spinal muscular atrophy, cystic fibrosis, and m…

This study is tracking the safety and performance of a device called ECE50 used during routine medical exams. It involves 384 adults who need a diagnosis for voice box muscle issues, like vocal fold paresis or laryngeal dystonia. The goal is to see if the device works as well as …

This study tests whether a personalized form of brain stimulation (TMS) combined with a medication can improve neck muscle control in people with cervical dystonia. Fifty adults with the condition will receive either real or sham TMS in a single day, along with the drug trihexyph…

This study compares biofeedback training to lifestyle changes (like special positions and massage) for women with dyssynergic defecation, a condition where pelvic floor muscles don't relax properly during bowel movements. About 58 women aged 35-65 with chronic constipation will p…

This study tests whether accelerated transcranial magnetic stimulation (TMS) can improve hand function and brain activity in people with focal hand dystonia, a condition causing involuntary muscle contractions during tasks like writing. Twenty-one adults will receive four TMS ses…

This study tests a program called FACE-Rare, designed to support family caregivers of children with rare, life-limiting diseases. The program includes three sessions to help families prepare for future medical decisions and improve their quality of life. Researchers will compare …

This study tests an experimental oral medication, MTR-601, for people with cervical dystonia, a condition causing painful neck muscle spasms and abnormal head posture. About 80 adults will receive either the drug or a placebo for 8 weeks to see if it safely reduces symptoms. The …

This study follows 214 men treated for prostate cancer to see how many develop lower limb lymphedema (leg swelling) and who is most at risk. Participants attend check-ups every three months for 18 months. The goal is to better understand this side effect and its impact on quality…

This study tests a new type of brain implant that can both sense brain activity and deliver stimulation in real time. It involves 25 people with Parkinson's disease or dystonia who already need deep brain stimulation. The goal is to see if closed-loop stimulation (which adjusts a…

This study is observing up to 198 people with rapid-onset dystonia-parkinsonism (RDP) or related genetic mutations. Researchers aim to identify affected individuals, document how common the disease is, and track its progression over time. Participants undergo assessments of sympt…

This study is building an online platform called DBS MatchMaker to connect doctors around the world who treat rare movement disorders with deep brain stimulation (DBS). The goal is to help doctors share knowledge and find the best ways to treat patients. Up to 500 people of all a…

This study looks at how different patterns of deep brain stimulation (DBS) affect movement symptoms and brain activity in people with Parkinson's disease, essential tremor, multiple sclerosis, or dystonia. Researchers will test non-regular stimulation patterns to find ways to mak…

This study was designed to find out if deep brain stimulation (DBS) in the thalamus, used to treat essential or dystonic tremor, also changes breathing. Researchers planned to measure breath-holding and peak airflow in a small group of patients before and after DBS surgery. Howev…

This study looks at how spasmodic dysphonia, a voice disorder causing uncontrollable vocal cord spasms, affects patients' jobs and social lives. Researchers will interview 20 adults who have received at least one botulinum toxin injection to understand if the treatment helps impr…

This study explores whether low-intensity ultrasound can safely and precisely stimulate deep brain regions in people with Parkinson's disease or dystonia. Ten participants who already have deep brain stimulation (DBS) implants will receive ultrasound pulses while researchers reco…