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Extramammary Paget disease
MONDO:0008177A malignant neoplasm in which there is infiltration of the skin by neoplastic large cells with abundant pale cytoplasm and large nuclei with prominent nucleoli (Paget cells). It may affect the anus, penis, scrotum, and vulva.
Also known as: Extramammary Paget's disease, Paget disease Extramammary, Paget's disease of skin, Paget's disease of the skin, Paget's skin disease, extramammary Paget disease, EMPD, Paget disease, EXTRAMAMMARY
2745 clinical trials for this condition and its sub-types, 7 tagged with Extramammary Paget disease itself.
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Sub-types of Extramammary Paget disease
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Vulval Paget disease 2 trials
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Anal Paget disease 1 trial
2 sub-types
- Anal canal Paget disease 1 trial
- Perianal skin Paget disease 1 trial
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Paget disease of the penis 0 trials
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New virus therapy takes on advanced cancers in first human trial
Disease control Recruiting nowThis early-phase study tests a new treatment called MQ710, a modified virus injected directly into tumors, alone or with the immunotherapy drug pembrolizumab. It is for people with advanced solid tumors (like skin cancer or head and neck cancer) that have not responded to standar…
Phase 1 • Sponsor: Memorial Sloan Kettering Cancer Center • Aim: Disease control
Last updated Aug 14, 2026 00:00 UTC
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New light treatment offers hope for rare vulvar cancer
Disease control Recruiting nowThis study is testing a new device called PAGETEX that uses light therapy (photodynamic therapy) to treat a rare skin condition called vulvar Paget's disease. The disease often comes back after surgery, so researchers want to see if this light treatment can control it better. Abo…
Sponsor: University Hospital, Lille • Aim: Disease control
Last updated Jun 27, 2026 12:29 UTC
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New hope for hard-to-treat cancers: experimental drug targets HER2-positive tumors
Disease control Recruiting nowThis study tests a drug called trastuzumab rezetecan in people with advanced solid tumors that have stopped responding to standard therapies. The drug is given every three weeks to 90 participants divided into three groups based on their cancer type. Researchers will measure how …
Phase 2 • Sponsor: Sheng Zhang • Aim: Disease control
Last updated Jun 27, 2026 08:07 UTC
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Glow-in-the-Dark dye could help surgeons spot hidden cancer cells
Symptom relief Recruiting nowThis study tests whether giving a fluorescent dye called fluorescein sodium before vulvectomy helps surgeons see and remove all extramammary Paget's disease cells. About 27 adults with noninvasive or microinvasive disease will receive the dye intravenously in the operating room. …
Phase 2 • Sponsor: Memorial Sloan Kettering Cancer Center • Aim: Symptom relief
Last updated Jun 27, 2026 08:10 UTC
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New registry aims to unlock secrets of rare gynecologic condition
Knowledge-focused Recruiting nowThis study is creating a registry of 100 women with extramammary Paget's disease (EMPD) of the vulva or perianal area. Researchers will collect health information, tissue samples, and skin swabs to learn more about the disease and the bacteria living on affected skin. The goal is…
Sponsor: Mayo Clinic • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:00 UTC